Head of Department of Molecular biology Palladin Institute of Biochemistry Ukraine
Oleksandr H. Minchenko is a Corresponding Member of the National Academy of Sciences of Ukraine, specializing in molecular biology, biochemistry, and endocrinology. He currently leads the Department of Molecular Biology at the Palladin Institute of Biochemistry. His research has significantly contributed to understanding gene expression regulation, particularly in the context of cancer, diabetes, and atherosclerosis.
Profile
Scopus
Education
🎓 Dr. Sc. in Molecular Endocrinology (1986) – Institute of Endocrinology and Metabolism, Kyiv, Ukraine
🎓 Ph.D. in Biochemistry (1974) – Institute of Pharmacology and Toxicology, Kyiv, Ukraine
🎓 M.S. in Biochemistry (1969) – Taras Shevchenko Kyiv National University, Kyiv, Ukraine
Experience
💼 2003 – Present: Head, Department of Molecular Biology, Palladin Institute of Biochemistry, NAS of Ukraine
💼 2007 – 2017: Deputy Director, Palladin Institute of Biochemistry
💼 2007 – 2012: Visiting Professor, INSERM, University Bordeaux 1, France
💼 2003 – 2004 & 2007: Visiting Professor, National Cancer Center, Japan
💼 1994 – 2002: Visiting Scientist, Thomas Jefferson University, Philadelphia, PA, USA
💼 1990 – 1994: Head, Department of Molecular Endocrinology, Institute of Endocrinology and Metabolism, Kyiv, Ukraine
Research Interests
🔬 Molecular Biology of Mitochondria: Investigating the genetic and biochemical mechanisms within mitochondria.
🔬 Alternative Splicing: Exploring how alternative splicing regulates gene expression.
🔬 Hormone and Cytokine Action: Studying molecular mechanisms of hormone and cytokine effects.
🔬 Hypoxic Regulation: Understanding gene expression under hypoxic conditions.
🔬 Cancer, Diabetes, and Atherosclerosis: Researching gene expression in these diseases.
🔬 ER Stress Signaling: Investigating endoplasmic reticulum stress in cancer and its implications for anti-cancer therapy.
Awards
🏅 2018: Medal for the 100th Anniversary of the NAS of Ukraine
🏅 2017: Distinction “For Professional Achievements”, NAS of Ukraine
🏅 2012: Honorary Diploma, Highest Certification Commission of Ukraine
🏅 2008: Medal “Petro Mohyla”, Ministry of Education and Science of Ukraine
🏅 2007: Palladin Award in Biochemistry, NAS of Ukraine
🏅 2001: “Certificate of Appreciation”, Thomas Jefferson University
🏅 1986: Medal “For Excellence in Public Health”, Ministry of Public Health
🏅 1980: Diploma of Honor, Academy of Medical Sciences
Publications
- Germanyuk Ya.L., Minchenko A.G. (1978). Effect of insulin on RNA and protein biosynthesis in liver mitochondria from normal and alloxan diabetic rats. Endocrinol. Exper., 12: 233-243. [Cited by 30 articles]
- Minchenko A.G. (1978). Effect of hydrocortisone on the biosynthesis of ribonucleic acids in mitochondria of the liver, heart, and spleen of alloxan diabetic rats. Probl. Endocrinol., 24(1): 64-68. [Cited by 25 articles]
- Minchenko A.G. (1979). Role of glucocorticoid hormones in the mitochondrial DNA replication. Probl. Endocrinol., 25(5): 52-56. [Cited by 20 articles]
- Gause G.G., Tomarev S.I., Dolgillevich S.M., Minchenko A.G., Skryabin K.G., Baev A.A. (1981). Determination of the location of the initiation site of replication and of ribosomal genes on a restriction map of Misgurnus fossilis loach mitochondrial DNA. Dokl. Akad. Nauk SSSR, 251: 999-1001. [Cited by 18 articles]
- Minchenko A.G. (1981). Expression of the liver mitochondrial genome in diabetes. Probl. Endocrinol., 27(1): 62-66. [Cited by 22 articles]
- Minchenko A.G. (1981). Hormonal control of expression of the mitochondrial genome region in animal cells. Probl. Endocrinol., 27(6): 74-79. [Cited by 15 articles]
- Komissarenko V.P., Tron’ko N.D., Minchenko A.G. (1982). Current hypotheses on the molecular mechanism of action of glucocorticoid hormones. Physiol. Zh., 28: 721-733. [Cited by 28 articles]
- Minchenko A.G. (1982). Hormonal control of the expression of a portion of the mitochondrial genome in animal cells. Neurosci. Behav. Physiol., 12: 514-518. [Cited by 19 articles]
- Pusyriov A.T., Minchenko A.G., Avdonina T.A., Mazo A.M. (1982). Identification of poly(A)+ -RNA from rat liver mitochondria from 5’-termininal nucleotide sequences. Mol. Biol. (Mosk.), 16: 1042-1047. [Cited by 21 articles]
- Germanyuk Ya.L., Minchenko A.G. (1982). Action of perorally administered sodium ribonucleate on RNA biosynthesis in the aortic, cardiac, liver, and kidney tissue of animals with experimental diabetes mellitus. Pharmacol. and Toxicol., 45: 50-52. [Cited by 16 articles]