Sara Marinelli| Neuropathy and pain| Women Researcher Award

Posted on by sciencefather

Dr.Sara Marinelli| Neuropathy and pain| Women Researcher Award

Sara Marinelli conducts research on the mechanisms of central and peripheral neurodegeneration, exploring neuroinflammation’s impact on neuropathies, pain transmission, and chronic pain modulation. Her work aims to identify novel molecular targets and discover innovative therapeutic drugs. Recent research focuses include neural mechanisms of degeneration and regeneration, autophagy, immune responses, and the influence of sex-related and metabolic factors on neuropathological conditions and pain perception. Her investigations also cover spinal cord injuries, amyotrophic lateral sclerosis, and innate immunity in peripheral degeneration.

Profiles

Scopus

Orcid

 

šŸ“šEducation and Training

Ā Ā šŸ“šĀ Ā Publications:

Sex-specific adipose tissue’s dynamic role in metabolic and inflammatory response following peripheral nerve injury:

Ā  Ā  Ā Authors: Vacca, V., Rossi, C., Pieroni, L., … Coccurello, R., Marinelli, S.

Ā  Ā  Ā  Journal: iScience, 2023, 26(10), 107914

From the Gender Gap to Neuroactive Steroids: Exploring Multiple Cases to Further Understand Neuropathic Pain

Ā  Ā  Ā  Authors: Marinelli, S., Coccurello, R.

Ā  Ā  Ā  Ā Journal: International Journal of Molecular Sciences, 2023, 24(10), 8577

A Step Forward: About the Progresses Made in the Second Edition of the Special Issue ā€œThe Multiple Mechanisms Underlying Neuropathic Painā€

Ā  Ā  Authors: Marinelli, S., Coccurello, R.

Ā  Ā  Ā Journal: International Journal of Molecular Sciences, 2023, 24(10), 859

XeominĀ®, a Commercial Formulation of Botulinum Neurotoxin Type A, Promotes Regeneration in a Preclinical Model of Spinal Cord Injury

Ā  Ā  Authors: Mastrorilli, V., De Angelis, F., Vacca, V., … Luvisetto, S., Marinelli, S.

Ā  Ā  Journal: Toxins, 2023, 15(4), 248

Role of Running-Activated Neural Stem Cells in the Anatomical and Functional Recovery after Traumatic Brain Injury in p21 Knock-Out Mice

Ā  Ā Authors: Battistini, J.I., Mastrorilli, V., Nicolis di Robilant, V., … Marinelli, S., Farioli Vecchioli, S.

Ā  Ā  Journal: International Journal of Molecular Sciences, 2023, 24(3), 2911

Wheel Running Adversely Affects Disease Onset and Neuromuscular Interplay in Amyotrophic Lateral Sclerosis Slow Progression Mouse Model

Ā  Ā  Authors: Golini, E., Marinelli, S., Pisu, S., … Dobrowolny, G., Mandillo, S.

Ā  Ā  Journal: Current Neurovascular Research, 2023, 20(3), pp. 362ā€“376

Caloric restriction as a nutrition strategy in counteracting peripheral neuropathies

Ā  Ā Author: Marinelli, S.

Ā  Ā Book: Diet and Nutrition in Neurological Disorders, 2023, pp. 767ā€“787

Endocannabinoid signaling in microglia

Ā  Ā Authors: Marinelli, S., Marrone, M.C., Di Domenico, M., Marinelli, S.

Ā  Ā Journal: GLIA, 2023, 71(1), pp. 71ā€“90

Sex Differences in Neuropathy: The Paradigmatic Case of MetFormin

Ā  Ā Authors: De Angelis, F., Vacca, V., Tofanicchio, J., … Coccurello, R., Marinelli, S.

Ā  Ā Journal: International Journal of Molecular Sciences, 2022, 23(23), 14503

 

Hai Huang| Prostate cancer| Best Researcher Award

Posted on by sciencefather

Prof. Hai Huang| Prostate cancer| Best Researcher Award

Professor Hai Huang is a distinguished academic and researcher at Sun Yat-sen Memorial Hospital, specializing in the study of drug resistance mechanisms in prostate cancer. His research primarily focuses on understanding how the tumor microenvironment affects resistance to androgen receptor-targeted therapies and chemotherapy, aiming to develop better treatment strategies and improve patient outcomes. With an impressive portfolio, Professor Huang has completed 30 research projects, published 97 journal articles in SCI and Scopus-indexed journals, authored 9 books, and holds 20 patents.

Profiles

Scopus

Orcid

 

šŸ“šAcademic and Professional Background:

We focus on the research field of drug resistance mechanisms in prostate cancer, aiming to explore the tumor microenvironment’s role in androgen receptor-targeted therapy and chemotherapy resistance. Our work seeks to improve therapeutic strategies and patient outcomes in prostate cancer treatment.

šŸ“ŠĀ Research and Innovations:

Completed/Ongoing Research Projects:Ā  30 , Citation Index:Ā  (Hai Huang[Author])Ā  ANDĀ  (Sun Yat-sen Memorial Hospital [Affiliation]) ,Consultancy/Industry Projects:Ā  Prostate Cancer , Books Published (ISBN): Ā 9 ,Ā Patents Published/Under Process: 20 , Journals Published (SCI, Scopus, etc.):Ā  97

šŸ¤Ā Collaborations:

Qin Jun:Ā CAS Key Laboratory of Tissue Microenvironment and Tumor, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Nutrition and Health, Shanghai Jiao Tong University School of Medicine (SJTUSM) & Chinese Academy of Sciences ,Ā Ā Gao Dong:Ā State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences

šŸ†Ā Professional Memberships:Ā 

American Urological Association, European Association of Urology

šŸ”¬Ā Areas of Research:Ā 

Prostate cancer treatment resistance

šŸ†Ā Contributions :

Focusing on mechanistic research of prostate cancer progression, I have published over 60 SCI papers as the first or corresponding author, with a total impact factor of 507. I have presented at numerous international urological conferences, sharing insights and advancements in prostate cancer treatment.

āœļøĀ Self-Declaration:

I authenticate that to the best of my knowledge, the information given in this form is correct and complete. If at any time I am found to have concealed any material information, my application shall be liable to be summarily terminated without notice. I have read the terms and conditions and other policies of the Awards and agree to them.

šŸ“š Publications :

  • šŸ§¬ Single-cell deconvolution algorithms analysis unveils autocrine IL11-mediated resistance to docetaxel in prostate cancer via activation of the JAK1/STAT4 pathway
    • Authors: Cheng, B., Li, L., Luo, T., Lai, Y., Huang, H.
    • Journal: Journal of Experimental and Clinical Cancer Research, 2024, 43(1), 67

 

  • šŸ”„ Correction: The key cellular senescence related molecule RRM2 regulates prostate cancer progression and resistance to docetaxel treatment
    • Authors: Cheng, B., Li, L., Wu, Y., Du, T., Huang, H.
    • Journal: Cell and Bioscience, 2024, 14(1), 17

 

  • šŸ”¬ A protein-encoding CCDC7 circular RNA inhibits the progression of prostate cancer by up-regulating FLRT3
    • Authors: Wang, Q., Cheng, B., Singh, S., Li, H., Huang, H.
    • Journal: npj Precision Oncology, 2024, 8(1), 11.

 

  • šŸ’Š Redox responsive polymeric nanoparticles enhance the efficacy of cyclin dependent kinase 7 inhibitor for enhanced treatment of prostate cancer
    • Authors: Tao, Y., Dai, C., Xie, Z., Wu, J., Huang, H.
    • Journal: Chinese Chemical Letters, 2024, 35(8), 109170

 

  • šŸ§© Cancer-associated fibroblasts promote enzalutamide resistance and PD-L1 expression in prostate cancer through CCL5-CCR5 paracrine axis
    • Authors: Xiong, Z., Yu, S.-L., Xie, Z.-X., Huang, H., Li, K.-W.
    • Journal: iScience, 2024, 27(5), 109674

 

  • šŸ§Ŗ MT1G, an emerging ferroptosis-related gene: A novel prognostic biomarker and indicator of immunotherapy sensitivity in prostate cancer
    • Authors: Cheng, B., Lai, Y., Huang, H., Wang, Q., Huang, H.
    • Journal: Environmental Toxicology, 2024, 39(2), pp. 927ā€“941

 

 

Jaebong Kim| Molecular and Cellular Biology| Best Researcher Award

Posted on by sciencefather

ProfĀ Jaebong Kim| Molecular and Cellular Biology| Best Researcher Award

 

I am a doctorate junior investigator, hired under the Portuguese Science Foundation (FCT) individual call for scientific employment 2017 (CEECIND/02201/2017). I graduated in Biology from the University of Coimbra (UC) in 2007 and completed a masterā€™s degree in Cellular and Molecular Biology from UC in 2008, scoring 18 out of 20. I obtained my Ph.D. in Cellular Biology from UC in 2013, achieving the highest distinction: Summa cum laude. In 2015, I was awarded a science management fellowship, and from 2016 to 2019, I received a national post-doc fellowship from FCT.

Profiles

Scopus

Orcid

ACADEMIC EDUCATION:

  • 1985: B.S. Agricultural Chemistry, Kyungpook National University, Taegu, Korea. 1987: M.S. Agricultural Chemistry, Kyungpook National University, Taegu, Korea. 1994: Ph.D. Biochemistry, University of Maryland, College Park, MD., USA. 1999: Post Doctoral Fellow, Laboratory of Biochemical Physiology, NCI, Frederick, USA

APPOINTMENTS AND PROFESSIONAL ACTIVITIES:

1983-1984: Army service, Taegu, Korea. 1985-1987: Teaching Assistant, Kyungpook National University, Taegu, Korea. 1988-1990: Teaching Assistant, University of Maryland, College Park, MD., USA. 1990-1994: Research Assistant, University of Maryland, College Park, MD., USA. 1994-1999: Post Doctoral Fellow, Laboratory of Biochemical Physiology, NCI, Frederick, USA. 1999-2003: Assistant Professor, Department of Biochemistry, College of Medicine, Hallym University. 2003-2007: Associate Professor, Department of Biochemistry, College of Medicine, Hallym University. 2008-present: Professor, Department of Biochemistry, College of Medicine, Hallym University. 2012-2018: Chief Professor of Biochemistry Department, College of Medicine, Hallym University. 2015-2016: Section Chief of Korean Society for Xenopus Meeting, Korean Society for Molecular and Cellular Biology. 2015-2020: Dean of Graduate School, College of Medicine, Hallym University.

RESEARCH FIELDS AND INTERESTS

Dr. Kim has made significant contributions to the field of biochemistry. He obtained his B.S. and M.S. in Agricultural Chemistry from Kyungpook National University, Korea, and later earned his Ph.D. in Biochemistry from the University of Maryland, USA. Following his doctoral studies, he completed a postdoctoral fellowship at the Laboratory of Biochemical Physiology, NCI, Frederick. Dr. Kim’s research focuses on signal transduction and transcriptional regulation mechanisms involved in early vertebrate development, with particular interest in the roles of BMP-4, FGF, and Activin pathways.

PROJECTS (2016-present):

  • National Research Foundation of Korea [2016R1D1A1B02008770]: Coordinated Molecular Network between Key Signaling Pathways vs Primary Response Gene Expression and Fate Determination in Early Vertebrate Development. Principal Investigator. 49,750,000 won/yr (2016-2024). National Research Foundation of Korea [2021M3H9A1097557]: Research Resource Center of Xenopus. Principal Investigator. 100,000,000 won/yr (2021-2026). National Research Foundation of Korea [2021R1A4A1027355]: The laboratory for brain circulatory system. Participant as a Basic Research Laboratory Fund. 100,000,000 won/yr (2021-2024). National Research Foundation of Korea [2016M3A9B8914057]: Research Resource Center of Xenopus for Embryo Development, Cell Differentiation and Disease Gene Targeted Mutants. Principal Investigator. 100,000,000 won/yr (2016-2021). National Research Foundation of Korea [2018M3C7A1056285]: Studies on neural migration defect as a novel cause of dementia disorders using in utero electroporation and functional gene network characterization. Principal Investigator. 84,164,000 won/yr (2018-2022)

Publications

  • Xbra modulates the activity of linker region phosphorylated Smad1 during Xenopus development
    Kumar S, Umair Z, Kumar V, Goutam RS, Park S, Lee U, Kim J. Sci Rep. 2024 Apr 18;14(1):8922. doi: 10.1038/s41598-024-59299-7.

 

  • Cdx1 and Gsc distinctly regulate the transcription of BMP4 target gene ventx3.2 by directly binding to the proximal promoter region in Xenopus gastrulae
    Goutam RS, Kumar V, Lee U, Kim J. Mol Cells. 2024 Apr;47(4):100058. doi: 10.1016/j.mocell.2024.100058. Epub 2024 Mar 23.

 

  • Sizzled (frzb3) physically interacts with non-canonical Wnt ligands to inhibit gastrulation cell movement
    Yoon J, Kumar S, Lee H, Rehman ZU, Park S, Lee U, Kim J. Mol Cells. 2024 May 15:100068. doi: 10.1016/j.mocell.2024.100068. Online ahead of print.

 

  • Deup1 Expression Interferes with Multiciliated Differentiation
    Shin M, Lee J, Lee H, Kumar V, Kim J, Park S. Mol Cells. 2023 Dec 31;46(12):746-756.

 

  • Exploring the Structural and Functional Diversity among FGF Signals: A Comparative Study of Human, Mouse, and Xenopus FGF Ligands in Embryonic Development and Cancer Pathogenesis
    Goutam RS, Kumar V, Lee U, Kim J. Int J Mol Sci. 2023 Apr 20;24(8):7556.

 

  • Two Homeobox Transcription Factors, Goosecoid and Ventx1.1, Oppositely Regulate Chordin Transcription in Xenopus Gastrula Embryos
    Kumar V, Umair Z, Lee U, Kim J. Cells. 2023 Mar 11;12(6):874.

 

  • Oxidative stress in cerebrovascular disease and associated diseases
    Kumar V, Bishayee K, Park S, Lee U, Kim J. Front Endocrinol (Lausanne). 2023 Feb 17;14:1124419.

 

  • Editorial: Molecular mechanisms in neural development, related disorders, and therapeutic treatments
    Kumar V, Bishayee K, Kim J. Front Mol Neurosci. 2023 Jan 13;16:1135491.

 

  • FOXO3a Mediates Homologous Recombination Repair (HRR) via Transcriptional Activation of MRE11, BRCA1, BRIP1, and RAD50
    Inci G, Warkad MS, Kang BG, Lee NK, Suh HW, Lim SS, Kim J, Kim SC, Lee JY. Molecules. 2022 Dec 6;27(23):8623.

 

  • Bmp4 Synexpression Gene, Sizzled, Transcription Is Collectively Modulated by Smad1 and Ventx1.1/Ventx2.1 in Early Xenopus Embryos
    Rehman ZU, Tayyaba F, Lee U, Kim J. Int J Mol Sci. 2022 Nov 1;23(21):13335.

 

  • Reversing the HDAC-inhibitor mediated metabolic escape in MYCN-amplified neuroblastoma
    Bishayee K, Nazim UM, Kumar V, Kang J, Kim J, Huh SO, Sadra A. Biomed Pharmacother. 2022 Jun;150:113032.

 

  • Ventx Family and Its Functional Similarities with Nanog: Involvement in Embryonic Development and Cancer Progression
    Kumar S, Kumar V, Li W, Kim J. Int J Mol Sci. 2022 Mar 1;23(5):2741.

 

  • Bmp Signal Gradient Modulates Convergent Cell Movement via Xarhgef3.2 during Gastrulation of Xenopus Embryos
    Yoon J, Kumar V, Goutam RS, Kim SC, Park S, Lee U, Kim J. Cells. 2021 Dec 24;11(1):44.

 

  • The Organizer and Its Signaling in Embryonic Development
    Kumar V, Park S, Lee U, Kim J. J Dev Biol. 2021 Nov 1;9(4):47.

 

  • Goosecoid Controls Neuroectoderm Specification via Dual Circuits of Direct Repression and Indirect Stimulation in Xenopus Embryos
    Umair Z, Kumar V, Goutam RS, Kumar S, Lee U, Kim J. Mol Cells. 2021 Oct 31;44(10):723-735.

 

 

Cristina Carvalho| Neurosciences and Metabolism | Women Researcher Award

Posted on by sciencefather

Dr Cristina Carvalho| Neurosciences and Metabolism | Women Researcher AwardĀ 

 

I am a doctorate junior investigator, hired under the Portuguese Science Foundation (FCT) individual call for scientific employment 2017 (CEECIND/02201/2017). I graduated in Biology from the University of Coimbra (UC) in 2007 and completed a masterā€™s degree in Cellular and Molecular Biology from UC in 2008, scoring 18 out of 20. I obtained my Ph.D. in Cellular Biology from UC in 2013, achieving the highest distinction: Summa cum laude. In 2015, I was awarded a science management fellowship, and from 2016 to 2019, I received a national post-doc fellowship from FCT.

Profiles

Scopus

Orcid

google scholarĀ 

Research and Innovations

Completed/Ongoing Research Projects

  • šŸ”¬ Total Projects: 8

Citation Index

  • šŸ“Š Scopus: 29
  • šŸ“ˆ Google Scholar: 35

Editorial Appointments

  • šŸ“ Guest Editor of 6 Special Issues in international journals over the last 5 years:
    • šŸ§¬ 1 in Biochimica et Biophysica Acta (IF=6.63, Q1)
    • šŸ§Ŗ 2 in Antioxidants (IF=7.675, Q1)
    • šŸ§« 3 in Biomedicines (IF=4.757, Q1)
    • šŸ„ˆ The Special Issue titled ā€œAD: 115 Years after Its Discoveryā€ published in Biomedicines ranked 2nd in the Top 10 most successful Special Issues of 2022.
    • šŸŽ¤ Invited to chair the 3rd Biomedicines Webinar ā€œAD: The History of Forgettingā€, which was open to both the scientific community and the general public.
    • šŸŒŸ Currently a board member of Biomedicines.

Publications

  • Protective effects of 2,4-dinitrophenol in okadaic acid-induced cellular model of Alzheimer’s disease
    Cardoso, S., Carvalho, C., Correia, S.C., Moreira, P.I.
    Biochimica et Biophysica Acta – Molecular Basis of Disease, 2024, 1870(6), 167222

 

  • MitoTempo protects against nĪµ-carboxymethyl lysine-induced mitochondrial dyshomeostasis and neuronal cells injury
    Carvalho, C., Moreira, P.I.
    Free Radical Biology and Medicine, 2024, 220, pp. 192ā€“206

 

  • Special Issue ā€œAlzheimerā€™s Diseaseā€”115 Years after Its Discoveryā€
    Cardoso, S., Carvalho, C., Correia, S.C.
    Biomedicines, 2024, 12(3), 478

 

  • Metabolic defects shared by Alzheimer’s disease and diabetes: A focus on mitochondria
    Carvalho, C., Moreira, P.I.
    Current Opinion in Neurobiology, 2023, 79, 102694

 

  • WWOX inhibition by Zfra1-31 restores mitochondrial homeostasis and viability of neuronal cells exposed to high glucose
    Carvalho, C., Correia, S.C., SeiƧa, R., Moreira, P.I.
    Cellular and Molecular Life Sciences, 2022, 79(9), 487

 

  • Disrupted cellular quality control mechanisms in aging
    Carvalho, C., Pires, J.F., Moreira, P.I., Raimundo, N.
    Aging: From Fundamental Biology to Societal Impact, 2022, pp. 359ā€“384

 

  • Cognitive impairment in obesity and diabetes
    Carvalho, C., Moreira, P.I.
    Obesity and Diabetes: Scientific Advances and Best Practice, 2020, pp. 399ā€“414

 

  • Post-translational modifications in brain health and disease
    Correia, S.C., Carvalho, C., Cardoso, S., Moreira, P.I.
    Biochimica et Biophysica Acta – Molecular Basis of Disease, 2019, 1865(8), pp. 1947ā€“1948