Baran SEVEN | Molecular Biology | Best Paper Award

Published on by Molecular Biologist

Dr. Baran Seven | Molecular Biology | Best Paper Award

Doctorate | TST Fittings and Medical Devices Industry and Trade | Turkey

Dr. Baran Seven is a committed biologist whose academic journey reflects a deep focus on toxicology, molecular biology, and environmental sciences. He earned his undergraduate, master’s, and doctoral degrees in Biology from Giresun University. His research has primarily involved investigating the toxicological effects of various chemical compounds on in vivo models, particularly Swiss albino mice. Throughout his academic progression, he has actively participated in multiple national and international scientific projects, often examining the protective effects of natural plant extracts against induced toxicities. Dr. Seven has published extensively in peer-reviewed journals and has presented his findings at numerous scientific conferences. His work demonstrates an interdisciplinary approach, blending physiological, genetic, and biochemical methods to assess and mitigate toxicity. With a strong background in both laboratory research and academic collaboration, Dr. Seven continues to contribute significantly to the fields of environmental toxicology and biomedical sciences.

Professional Profile

Scopus

Education

Dr. Baran Seven completed his entire academic training in Biology at Giresun University, Turkey. He obtained his Bachelor’s degree in 2013, followed by a Master’s degree in 2015 under the supervision of Associate Professor Kültiğin Çavuşoğlu and Professor Kürşad Yapar. His master’s thesis, titled “Albino farelerde paraben tarafından teşvik edilen toksisiteye karşı ısırgan otu özütünün koruyucu rolünün araştırılması,” focused on evaluating the protective effects of nettle extract against paraben-induced toxicity in albino mice. Continuing his studies at the same institution, he earned his Ph.D. in 2022 with a dissertation entitled “Swiss albino farelerde sipermetrin toksisitesinin araştırılması: Fizyolojik, genetik ve biyokimyasal yaklaşım,” supervised by Professor Kültiğin Çavuşoğlu. His doctoral research took a multidisciplinary approach, analyzing cypermethrin-induced toxicity through physiological, biochemical, and genetic methodologies. This comprehensive education has provided Dr. Seven with a solid foundation in experimental biology and toxicology.

Experience

Dr. Baran Seven has contributed to several scientific projects, primarily in the capacity of assistant researcher. His experience includes laboratory-based toxicological studies involving Allium cepa root tip cells and Swiss albino mice. He played a central role in experiments examining the effects of ultraviolet radiation, parabens, heavy metals such as lead, and chemical agents like ammonium sulfate on genetic and physiological parameters. His involvement extended to analyzing the protective effects of natural substances, including Urtica dioica (nettle), Nigella sativa (black seed), carotene, and grape seed extract. Dr. Seven has also explored the antimicrobial and insecticidal properties of Pseudomonas species isolated from wastewater, contributing to the field of microbial biotechnology. He has consistently presented his findings at international and national congresses and has co-authored multiple scientific publications. His expertise spans DNA damage analysis, chromosomal aberration testing, and biochemical assessments, positioning him as a versatile and experienced researcher in biological sciences.

Research Interest

Dr. Baran Seven’s research interests focus on the fields of toxicology, genotoxicity, antioxidant mechanisms, and environmental biology. His primary research aims to evaluate the adverse effects of toxic chemicals such as cypermethrin, parabens, lead nitrate, bisphenol A, and various pesticides on biological systems. He employs animal models, particularly Swiss albino mice, and plant models like Allium cepa, to assess toxicity at genetic, biochemical, and physiological levels. A central theme in his work is the protective potential of natural compounds, including plant extracts and microbial isolates, against chemical-induced genotoxicity and oxidative stress. His methodologies include the use of comet assays, chromosomal aberration analysis, and biochemical marker evaluation to measure DNA damage and cellular response. Dr. Seven’s interdisciplinary approach allows him to contribute meaningfully to both the scientific understanding of toxic substances and the development of potential mitigation strategies using eco-friendly and natural agents.

Awards and Recognition

Although specific individual awards are not explicitly listed, Dr. Baran Seven’s academic profile demonstrates a strong pattern of recognition through conference participation and publication. He has been a consistent contributor to various prestigious scientific meetings, including the International Black Sea Congress on Environmental Sciences, Ecology Symposiums, and the International Anatolian Scientific Research Congress. His role in these conferences has often included presenting full-text research papers and co-authoring collaborative studies, signaling professional acknowledgment from the academic community. Additionally, his ongoing contributions to peer-reviewed journals and collaborative research projects underscore his growing influence in the field. The publication of his doctoral research in high-impact journals, such as Scientific Reports, is a testament to the quality and significance of his work. Dr. Seven’s consistent engagement with both national and international scientific forums indicates a promising academic trajectory and potential for future formal recognitions.

Top Noted Publications

Dr. Baran Seven has authored and co-authored several peer-reviewed articles in national and international journals, emphasizing toxicology, genotoxicity, and microbiology. Key publications include:

Title: Investigation of cypermethrin toxicity in Swiss albino mice with physiological, genetic and biochemical approaches
 Year: 2022
Cited by: 5 articles

Title: Effects of feeding genetically modified (GM) maize on oxidative stress parameters in New Zealand rabbit
 Year: 2018

Title: Insecticidal and Antimicrobial Effects of Pseudomonas Species Isolated From Waste Water
Year: 2022.

Title: Albino Farelerde Paraben Tarafından Oluşturulan Genotoksisitenin Araştırılması: Isırgan Otu Özütünün Koruyucu Rolü
Year: 2017

Conclusion

Dr. Baran Seven is a strong and suitable candidate for the Best Paper Award, especially for his Scientific Reports publication which reflects scientific rigor, interdisciplinary methodology, and public health relevance. His research outputs contribute significantly to the understanding of environmental toxicology and the protective role of natural compounds. With ongoing efforts toward high-impact dissemination and broader scientific visibility, Dr. Seven is poised to make continued valuable contributions to the field.

Guoyin Liu | Molecular Biology | Best Researcher Award

Published on by Molecular Biologist

Assoc. Prof. Dr. Guoyin Liu | Molecular Biology | Best Researcher Award 

Attending physician and associate professor, at Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210093, China.

Dr. Guoyin Liu is an accomplished attending physician and associate professor at Jinling Hospital, Nanjing University, renowned for his expertise in orthopedics, inflammatory signaling, and regenerative medicine. Holding a PhD from Nanjing Medical University, he specializes in endoplasmic reticulum (ER) molecular chaperones such as GRP78/Bip and their role in critical orthopedic conditions including rheumatoid arthritis, osteoarthritis, chronic wounds, and periprosthetic osteolysis. Beyond molecular research, he pioneers innovative treatments like extracorporeal shock wave therapy, needle-knife therapy, and restorative laminoplasty techniques for spinal reconstruction. His translational research bridges basic science with clinical applications, contributing to novel interventions for musculoskeletal disorders. With an impressive portfolio of high-impact publications, key research grants, patents, and editorial board memberships, Dr. Liu exemplifies a commitment to advancing orthopedic science and patient care. His innovative contributions continue to shape the future of orthopedic diagnostics and treatments, fostering breakthroughs in bone regeneration and inflammatory disease management.

Professional Profile

Scopus

ORCID

🎓 Education 

Dr. Liu completed his PhD at Nanjing Medical University, focusing on the molecular mechanisms underlying inflammatory bone loss and tissue degeneration. His academic foundation integrates basic medical sciences, clinical orthopedics, and bioengineering approaches, enabling him to investigate complex orthopedic diseases at the cellular and molecular levels. During his training, he mastered advanced experimental techniques, including finite element biomechanical analysis, tissue engineering methodologies, and translational clinical trials. Dr. Liu expanded his academic horizon through specialized workshops in regenerative medicine, musculoskeletal biomechanics, and immunomodulation therapies. His education laid the groundwork for his pioneering research on GRP78/Bip signaling pathways in chronic musculoskeletal diseases. By blending clinical insights with experimental rigor, he has become a leading voice in developing innovative therapies for orthopedic patients. His educational journey reflects a seamless integration of theory and practice, empowering him to address both clinical challenges and fundamental biomedical questions with cutting-edge research approaches.

💼 Experience 

With over 15 years of combined clinical and research experience, Dr. Guoyin Liu has established himself as a leading expert in orthopedic surgery, translational research, and regenerative medicine. As an Attending Physician and Associate Professor at Jinling Hospital, he manages complex cases such as spinal deformities, chronic joint diseases, and osteolytic conditions. His academic tenure includes supervising multidisciplinary research projects funded by National Natural Science Foundation of China and provincial grants focusing on inflammatory pathways and bone regeneration. He has innovated surgical techniques like restorative laminoplasty with miniplate fixation, which has improved postoperative spinal stability and patient recovery outcomes. His extensive clinical experience is complemented by editorial board appointments in reputed international journals, reflecting his scientific leadership. Dr. Liu’s dual role as a clinician and researcher enables him to directly translate benchside discoveries into bedside applications, ensuring tangible benefits for patients suffering from chronic orthopedic disorders.

🔬 Research Interests 

Dr. Liu’s research is centered on cellular stress responses and inflammatory pathways in orthopedic diseases, with a special focus on endoplasmic reticulum molecular chaperones (GRP78/Bip) and their dual intracellular and extracellular roles. He investigates how particle-induced osteolysis, rheumatoid arthritis, and intervertebral disc degeneration are driven by inflammatory cascades, aiming to develop targeted molecular therapies. Another significant area of his research explores chemical chaperones like 4-Phenylbutyrate, which mitigate ER stress and improve bone regeneration. Dr. Liu also advances biomechanical engineering solutions, analyzing finite element models to improve spinal fixation techniques. Additionally, he integrates shockwave therapy, corticosteroid injections, and minimally invasive interventions for managing chronic orthopedic pain. His translational approach bridges basic science, bioengineering, and clinical orthopedics, leading to innovative strategies that reduce surgical complications and improve musculoskeletal repair. Through his research, Dr. Liu aims to redefine the diagnosis, prevention, and treatment of bone and joint diseases in aging populations.

🏆 Awards & Honors 

Dr. Liu has received numerous academic and clinical recognitions for his groundbreaking work in orthopedics. He was honored with the Third Prize for Military Science & Technology Progress for elucidating the TIM3 signaling pathway in osteoarthritis during military training-related injuries. Additionally, he received the Third Award for Nanjing Science & Technology Progress for identifying the role of recombinant BMP-1 in periprosthetic osteolysis. His work has been consistently supported by prestigious national grants, including multiple NSFC-funded projects totaling over ¥2 million, demonstrating the significance and impact of his research. Beyond awards, his appointment to editorial boards of leading orthopedic and bioengineering journals highlights his global recognition in the field. Dr. Liu’s innovative surgical methods, such as restorative laminoplasty with H-shaped miniplates, have been acknowledged as transformative in spinal reconstruction. These accolades collectively recognize his outstanding contribution to orthopedic research, surgical innovation, and patient care.

📚 Top Noted Publications 

Dr. Liu’s publications span orthopedic biomechanics, inflammatory pathways, and regenerative medicine, widely cited in the global research community. Key works include:

🛠️ Biomechanical Stability of Miniplates in Restorative Laminoplasty

Title: Comparative Biomechanical Stability of the Fixation of Different Miniplates in Restorative Laminoplasty after Laminectomy: A Finite Element Study
Authors: Guoyin Liu, Weiqian Huang, Nannan Leng, Peng He, Xin Li, Muliang Lin, Zhonghua Lian, Yong Wang, Jianmin Chen, Weihua Cai
Journal: Bioengineering (Basel)
Year / Volume / Issue: 2024; 11(5):519
DOI: 10.3390/bioengineering11050519 PubMed+15MDPI+15ResearchGate+15
Highlights: Used a finite element model (L2–L4) to compare H‑shaped, L‑shaped, and two‑hole miniplates. The H‑shaped design showed superior stability, especially in axial rotation and flexion/extension PubMedMDPI.

Biomechanical Reconstruction of the Posterior Complex in Laminoplasty

Title: Biomechanical evaluation of reconstruction of the posterior complex in restorative laminoplasty with miniplates
Authors: Jianmin Chen, Guoyin Liu, Tianyi Bao, Yuansheng Xu, Hu Luo, Yu Wu, Dawei Cai, Feng Qin, Jianning Zhao
Journal: BMC Musculoskeletal Disorders
Year / Volume / Article: 2023; 24(1):298
DOI: 10.1186/s12891-023-06380-3 PubMedOUCI
Highlights: Cadaveric 3D-printed L4 models under static/dynamic loading. H‑shaped miniplates outperformed L‑shaped and two-hole systems, preventing lamina collapse or plate breakage PubMedResearchGate.

Macrophage Apoptosis Pathways in Periprosthetic Osteolysis

Title: Apoptotic pathways of macrophages within osteolytic interface membrane in periprosthetic osteolysis
Journal: APMIS
Year: 2017
Details: Demonstrates that wear particles at implant interfaces accelerate macrophage apoptosis via ER-stress and mitochondrial dysfunction, which exacerbates osteolysis PubMedPhysiology Journals.

Endoplasmic Reticulum Stress and Osteolysis

Title: Endoplasmic reticulum stress-mediated inflammatory signaling pathways within the osteolytic periosteum and interface membrane in particle-induced osteolysis
Authors: Guoyin Liu, Naicheng Liu, Yuansheng Xu, Yunfan Ti, Jiangning Chen, Jianmin Chen, Junfeng Zhang, Jianning Zhao
Journal: Cell and Tissue Research
Year / Issue / Pages: 2016 Feb; 363(2):427–447
DOI: 10.1007/s00441-015-2205-9 PubMedSpringerLink
Highlights: Particle debris induces ER stress in macrophages, triggering IRE1α, GRP78/BiP, NF‑κB pathways, elevating pro-inflammatory cytokines (TNF‑α, IL‑1β, IL‑6). 4‑PBA effectively reduced ER-stress and osteolysis in murine models .

Conclusion

Dr. Guoyin Liu’s outstanding contributions to orthopedic research, innovative therapies, and patented medical devices make him a highly suitable candidate for the Best Researcher Award. His work bridges basic molecular research with clinical applications, significantly improving diagnosis, treatment, and rehabilitation of complex musculoskeletal disorders.