Doctorate, at RETIRED, United States.
Dr. Fusun Kilic is a retired Professor of Biochemistry and Cellular Molecular Biology with a distinguished career spanning over three decades. Her expertise includes kinetic measurements of transporters, membrane protein modification, and protein-protein interactions. Her pioneering research focused on serotonin (5-HT) signaling, particularly its role in remodeling cell surface N-glycans and post-translational modifications of serotonin transporters (SERT). Dr. Kilic has trained numerous MD/Ph.D. students, published extensively, and received prestigious awards such as the Red Sash and Mentor Awards. She also organized and chaired the 2017 Keystone Symposium “Frontier of Serotonin Beyond the Brain.”
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🎓 Education
Dr. Kilic’s academic journey reflects a dedication to excellence. She completed her Ph.D. in Biochemistry, where she developed an interest in membrane transport proteins and cellular signaling mechanisms. During her postdoctoral training at Yale University, she made groundbreaking contributions to understanding SERT oligomerization and functional consequences. Throughout her career, Dr. Kilic combined her deep biochemical expertise with innovative approaches to studying serotonin’s physiological roles, influencing the broader field of molecular pharmacology.
🧪 Experience
Dr. Kilic has held esteemed academic and research positions, most notably as a professor specializing in biochemistry and cellular molecular biology. She spent significant years at the University of Arkansas for Medical Sciences (UAMS), where she built a robust research program investigating serotonin signaling pathways. Her laboratory became a hub for training future scientists, contributing to key discoveries about SERT’s role in membrane trafficking and its implications for cardiovascular health. Her professional contributions extended to organizing international symposiums and mentoring early-career researchers.
🔍 Research Interests
Dr. Kilic’s research primarily focused on serotonin signaling and transporter mechanisms, particularly the post-translational modifications of SERT. She explored how extracellular 5-HT interacts with plasma membrane-bound SERT across various organ systems during health and disease states. Her studies delved into the glycosylation and oligomerization of SERT, uncovering their impact on membrane trafficking and platelet function. Additionally, she examined the implications of elevated plasma serotonin levels in hypertension, shedding light on the complex interplay between serotonin, platelet physiology, and cardiovascular health.
🏆 Awards
Dr. Kilic’s dedication and contributions have earned her numerous accolades. She received the prestigious Red Sash Award and the Mentor Award from the College of Medicine, recognizing her commitment to education and mentorship. She also chaired the renowned Keystone Symposium “Frontier of Serotonin Beyond the Brain,” highlighting her leadership in the field. These awards reflect her impact not only as a researcher but also as an inspiring mentor and leader in biochemical sciences.
📚Top Noted Publications
Dr. Kilic has authored influential research articles in high-impact journals, advancing our understanding of serotonin signaling:
- 1. Kilic F., Rudnick G. (2000)Title: Oligomerization of the serotonin transporter and its functional consequences
Journal: Proceedings of the National Academy of Sciences (PNAS)
Volume/Issue: 97, pp. 3106-3111
Key Findings:
This study explores the oligomeric nature of the serotonin transporter (SERT) and demonstrates that SERT functions in oligomeric complexes. This oligomerization is crucial for proper transport function and regulation.
Citations: 250+
2. Li, Y., et al. (2014)
Title: GDM-associated insulin deficiency hinders SERT dissociation from ERp44
Journal: Proceedings of the National Academy of Sciences (PNAS)
Volume/Issue: 111, pp. 52
Key Findings:
This research investigates the impact of gestational diabetes mellitus (GDM) on serotonin transporter (SERT) function. It highlights that insulin deficiency linked to GDM interferes with the dissociation of SERT from ERp44, impacting serotonin homeostasis.
Citations: 180+
3. Maroteaux L., Kilic, F. (2019)
Title: Frontiers of Serotonin beyond the brain
Journal: Pharmacological Research
Volume/Issue: 140, pp. 1-6
Key Findings:
This review discusses the emerging roles of serotonin beyond its traditional neurological functions. It highlights the impact of serotonin in peripheral systems and its potential therapeutic implications.
Citations: 100+
4. Lowery III, C. L., Kilic, F. (2019)
Title: Serotonin and platelet transporter response to smoking
Journal: Frontiers in Neuroscience
Volume/Issue: 13, Article 32
Key Findings:
The study examines the effects of smoking on serotonin levels and platelet serotonin transporter (SERT) activity. It provides insights into the modulation of peripheral serotonin by smoking, with potential cardiovascular implications.
Citations: 90+
5. Brenner, B., et al. (2007)
Title: Plasma serotonin and platelet serotonin transporter
Journal: Journal of Neurochemistry
Volume/Issue: 102(1), pp. 206-216
Key Findings:
This research delves into the role of plasma serotonin and the activity of platelet SERT. It underscores the importance of platelet SERT in regulating peripheral serotonin levels and its clinical relevance.
Citations: 150+
Conclusion
Dr. Fusun Kilic’s extensive research, mentorship, and leadership in serotonin transporter studies position her as a strong candidate for the Best Extension Activity Award. With a focus on translating complex biochemical research into clinical and community applications, her contributions demonstrate significant societal impact. Enhancing the application with concrete examples of public outreach and measurable outcomes will further solidify her case for this prestigious recognition.