Post doctoral scientists, at University of Miami, United States.
Dr. Mayur A. Doke is an accomplished molecular biologist specializing in pancreatic plasticity and exocrine-endocrine interactions. His research leverages advanced bioinformatics and single-cell RNA sequencing to investigate tissue dynamics. With a strong foundation in molecular biology, he is recognized for his contributions to understanding complex biological processes through innovative techniques such as RNA-Seq, methylation sequencing, and calcium signaling. Dr. Doke has an impressive track record with 16 peer-reviewed publications, demonstrating his expertise in molecular biology and bioinformatics.
Profile
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Education
Dr. Doke holds a PhD in Cancer Biology from Florida International University (2013-2018), where he focused on the role of ID3 and endocrine-disrupting chemicals in proliferative vascular lesions leading to diseases such as pulmonary artery hypertension and non-small cell lung cancer. He earned his Master’s (M.Sc.) and Bachelor’s (B.Sc.) degrees in Environmental Science and Biotechnology, respectively, from Mumbai University.
Experience
Dr. Doke is currently a Postdoctoral Researcher at the Diabetes Research Institute, University of Miami, where he employs cutting-edge techniques such as single-cell RNA sequencing and pancreatic slice cultures. His prior experience includes positions at Texas A&M University and the Icahn School of Medicine at Mount Sinai, where he worked on modeling HIV neuropathology, epigenetic signatures, and RNA sequencing. His diverse skill set spans molecular biology, bioinformatics, and high-performance computing, making him a versatile researcher in his field.
Research Interests
Dr. Doke’s research interests lie in understanding the molecular underpinnings of tissue plasticity, particularly in pancreatic and brain tissues. His expertise encompasses bioinformatics, scRNA-seq analysis, epigenetics, and metabolomics, with a focus on the effects of environmental disruptors and diseases like HIV on cellular functions. He is particularly interested in the intersection of molecular biology and computational biology to uncover new insights into human disease mechanisms.
Awards
Throughout his academic journey, Dr. Doke has been recognized for his scientific contributions, receiving accolades for his research and presentations at national and international platforms. His dedication to advancing the fields of molecular biology and bioinformatics has earned him recognition from his peers and institutions alike.
Publications
Dr. Doke has published extensively in prestigious journals. His work includes:
- Doke, M., et al. (2023). Dynamic scRNA-seq of live human pancreatic slices reveals functional endocrine cell neogenesis through an intermediate ducto-acinar stage.
Journal: Cell Metabolism
DOI: Not provided (please provide the exact DOI to retrieve more specific details).
Summary: This study employs single-cell RNA sequencing (scRNA-seq) on live human pancreatic slices to uncover the process of endocrine cell neogenesis. It identifies an intermediate stage involving ducto-acinar cells, suggesting a new pathway for the formation of functional endocrine cells, which may be crucial for understanding pancreatic regeneration and diabetes.
- Doke, M., et al. (2023). Genomic Alterations and Aberrant Molecular Pathways in Arrhythmogenic Cardiomyopathy.
Journal: The American Journal of Cardiology
DOI: Not provided (please provide the exact DOI for more details).
Summary: This research explores the genetic mutations and disrupted molecular pathways that contribute to arrhythmogenic cardiomyopathy (ACM). It highlights specific genomic alterations and offers insight into the disease’s pathology, providing potential targets for therapeutic interventions.
- Avecilla, V., Doke, M., et al. (2017). Contribution of Inhibitor of DNA Binding/Differentiation-3 and Endocrine Disrupting Chemicals to Pathophysiological Aspects of Chronic Disease.
Journal: BioMed Research International
DOI: Not provided (please provide the exact DOI for additional information).
Summary: This paper investigates the role of the Inhibitor of DNA Binding/Differentiation-3 (ID3) protein and endocrine-disrupting chemicals (EDCs) in the development of chronic diseases. It suggests that ID3 and EDCs may influence gene expression and contribute to the onset of conditions such as cancer, diabetes, and cardiovascular diseases.
- Doke, M., et al. (2020). HIV-1 Tat and cocaine impact mitochondrial epigenetics: effects on DNA methylation.
Journal: Epigenetics
DOI: Not provided (please provide the exact DOI for specifics).
Summary: This study examines the combined effects of the HIV-1 Tat protein and cocaine on mitochondrial epigenetics. The findings reveal that both factors alter DNA methylation patterns, particularly in genes related to mitochondrial function, providing insights into how HIV and substance abuse may contribute to cellular damage and disease progression.
Conclusion
Dr. Mayur A. Doke’s extensive expertise in molecular biology, bioinformatics, and innovative research techniques, along with his significant publication record, makes him a highly suitable candidate for the Best Researcher Award. His ability to contribute to both foundational and applied research in areas like pancreatic biology and HIV neuropathology highlights his versatility and commitment to advancing science. Expanding his leadership in independent research projects and securing additional funding would further solidify his position as a top researcher in the scientific community.