Professor, at China Pharmaceutical University, China.
Dr. Hongxi Wu is a distinguished Research Fellow, Associate Professor, and Graduate Supervisor at the Department of Pharmacology, School of Pharmacy, China Pharmaceutical University. With extensive experience in molecular pharmacology and precision oncology, his research focuses on understanding gene regulatory mechanisms in cancer progression and drug resistance. Dr. Wu has made significant contributions to prostate and liver cancer treatment by identifying novel biomarkers and therapeutic targets. As a leading investigator, he has secured multiple national-level grants and published extensively in high-impact journals. His work bridges fundamental research with clinical applications, aiming to enhance cancer therapy outcomes through innovative drug discovery.
Professional Profile
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ORCID
Education 🎓
Dr. Wu pursued his academic journey at China Pharmaceutical University. He earned his Bachelor’s degree in Pharmacoeconomics (2007-2011), followed by a Master’s degree in Pharmacology (2011-2014). He continued his Ph.D. research in Pharmacology (2014-2017), investigating molecular mechanisms underlying cancer progression and drug resistance. Dr. Wu then advanced his expertise as a Postdoctoral Research Scientist (2017-2021), further exploring targeted therapies for castration-resistant prostate cancer and hepatocellular carcinoma. His educational background laid a strong foundation for his innovative research in cancer pharmacology.
Research Experience 👩🎓
Dr. Wu’s research delves into the molecular mechanisms of gene regulation in cancer, focusing on castration-resistant prostate cancer and liver cancer. He has identified key biomarkers, including AR and ARv7 variants, IRF8, CDK9, and CLKs, which influence prognosis and drug efficacy. His work extends to developing novel combination therapies, such as 2-Methoxyestradiol with Erlotinib and sorafenib with enzalutamide, to enhance treatment effectiveness. Additionally, he investigates innovative anticancer compounds targeting AR, CDK9, and Clk1/2 through chemical biology strategies, aiming to overcome drug resistance in precision oncology.
Research Interests 🎡
Dr. Wu’s primary research interests lie in cancer pharmacology, precision medicine, and targeted therapies. He focuses on understanding tumor progression, metastasis, and drug resistance mechanisms. His work aims to identify novel therapeutic targets and develop personalized treatment strategies for aggressive cancers. Dr. Wu is particularly interested in androgen receptor biology, immune response modulation, and the role of gene expression in chemotherapy resistance. His research integrates molecular biology, pharmacogenomics, and chemical biology to develop innovative cancer treatments.
Awards & Honors 🏆
Dr. Wu has received several prestigious awards recognizing his contributions to cancer research. In 2023, he was honored with the SHIMADZU Young Scholar’s Award for his groundbreaking work in pharmacology. He has also secured multiple research grants, including funding from the National Natural Science Foundation of China, the Natural Science Foundation of Jiangsu Province, and the China Postdoctoral Science Foundation. His outstanding research achievements have earned him national and international recognition, further solidifying his reputation as a leading cancer pharmacologist.
Top Noted Publications 📚
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Wu H, et al. (2024). Discovery of CLKs inhibitors for the treatment of non-small cell lung cancer.
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Wu H, et al. (2023). Flavonoid-based CDK9 degraders for prostate cancer treatment.
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Wu H, et al. (2022). Hepatic IRF8 expression suppresses hepatocellular carcinoma progression and enhances anti-PD1 therapy.
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Wu H, et al. (2022). A novel AR inhibitor induces protein degradation to overcome enzalutamide resistance in prostate cancer.
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Wu H, et al. (2020). Loss of IRF8-AR feedback promotes prostate cancer growth and enzalutamide resistance.
Conclusion
Dr. Hongxi Wu is an exceptionally strong candidate for the Best Researcher Award, given his outstanding contributions to oncology pharmacology, impactful publications, and success in securing competitive research grants. While further international collaborations, industry engagement, and leadership in global research networks could further enhance his profile, his achievements in cancer research, particularly in overcoming drug resistance, make him a highly deserving nominee.