Yong-Xiao Wang | Drug Discovery Research | Best Researcher Award

Dr. Yong-Xiao Wang | Drug Discovery Research | Best Researcher Award 

Principal Investigator, at Albany Medical College, United States.

Dr. Yong-Xiao Wang is a distinguished professor in Molecular & Cellular Physiology at Albany Medical College. With a profound dedication to cardiovascular and respiratory research, he has become a key figure in exploring molecular mechanisms within these fields. His research examines cell calcium signaling, ion channels, and reactive oxygen species in cardiovascular and respiratory systems. Dr. Wang has garnered substantial funding through NIH and AHA grants, contributing to groundbreaking discoveries in cellular signaling pathways. A prolific author, he has published extensively in high-impact journals, such as Nature and Proceedings of the National Academy of Sciences. Dr. Wang also actively participates in scientific editorial boards and professional societies, embodying a deep commitment to advancing translational medicine and mentoring future leaders in physiology and pharmacology.

Profile

Scopus

Education 🎓

Dr. Wang completed his M.D. equivalent in 1983 from Wannan Medical College, China, setting the foundation for his medical and scientific journey. He pursued advanced studies at the Fourth Military Medical University in Xian, earning his M.S. in 1986 and later a Ph.D. in 1990. This robust academic background enabled him to acquire deep insights into pharmacology and physiology, essential for his focus on cardiovascular and respiratory biology. His education honed his expertise in molecular biology, with an emphasis on cell signaling mechanisms and regulatory pathways, forming the basis for his impactful research career in molecular and cellular physiology.

Experience 📚

Dr. Wang’s professional trajectory spans several decades and prestigious institutions. He has served as a tenured professor at Albany Medical College since 2006. Previously, he held roles as an associate professor and senior research associate at Cornell University and the University of Pennsylvania, where he gained extensive research experience. Early in his career, Dr. Wang held positions at the Fourth Military Medical University in China. His multifaceted experience encompasses research, teaching, and mentorship, reinforcing his expertise in translational medicine and his commitment to innovation in cardiovascular and respiratory sciences.

Research Interests 🔬

Dr. Wang’s research focuses on cardiovascular and respiratory biology, particularly investigating cellular signaling mechanisms. His studies delve into calcium signaling, ion channels, reactive oxygen species, and neurotransmitter receptors in cardiovascular and respiratory systems. Dr. Wang employs molecular, biochemical, and pharmacological approaches to understand these processes, aiming to uncover therapeutic pathways for heart and lung diseases. His translational research bridges cellular mechanisms and clinical applications, aiming to develop novel therapies for conditions such as pulmonary hypertension and cardiac hypertrophy, underscoring his commitment to advancing human health.

Awards 🏆

Dr. Wang has been recognized widely for his contributions to medical research. His accolades include the American Heart Association’s Established Investigator Award in 2003 and the Scientist Development Award in 1998. In 2020, he was elected a Fellow of the American Physiology Society, reflecting his influence in the field. Additionally, he has received Outstanding Research Awards from the Chinese Heart Association and Chinese Pharmacology Society, acknowledging his research impact across both national and international platforms. Dr. Wang’s awards highlight his consistent excellence in cardiovascular and respiratory research.

Top Noted Publications 📑

Dr. Wang has authored numerous influential publications in high-impact journals, reflecting his extensive contributions to cardiovascular and respiratory research. Key publications include:

  • “Effects of doxorubicin on excitation-contraction coupling in guinea-pig ventricular myocardium”
    Published in Circulation Research, 1995

    • This study explores the cellular mechanisms by which doxorubicin, a chemotherapeutic agent, affects heart muscle contraction. It investigates the impact on excitation-contraction coupling in guinea pig ventricular myocardium, shedding light on the cardiovascular side effects of doxorubicin treatment.
    • Cited by: 500+ articles
  • “Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy”
    Published in Nature, 2002

    • This research delves into the protective role of oestrogen in preventing cardiac hypertrophy in FKBP12.6 null mice. The study highlights the significance of estrogen in modulating cardiac function and its potential therapeutic implications in preventing heart enlargement and dysfunction.
    • Cited by: 1000+ articles
  • “Rieske iron-sulfur protein induces remodeling of FKBP12.6/RyR2 complex”
    Published in Nature Communications, 2020

    • This paper examines the role of the Rieske iron-sulfur protein in the remodeling of the FKBP12.6/RyR2 complex, a critical component of the calcium release channel in cardiac muscle cells. This work helps to understand the molecular basis of arrhythmias and cardiac dysfunction.
    • Cited by: 200+ articles

Conclusion

Dr. Yong-Xiao Wang is a highly qualified candidate for the Research for Best Researcher Award. His significant contributions to the understanding of molecular mechanisms in respiratory and cardiovascular diseases, along with his extensive publication record, grant achievements, and leadership in academia, underscore his suitability for this recognition. With continued focus on interdisciplinary research and public health applications, Dr. Wang’s influence in the biomedical sciences could become even more impactful, making him a compelling choice for this award.

 

OUSSEMA KHAMESSI | molecular docking | Best Researcher Award

Assist Prof Dr. OUSSEMA KHAMESSI | molecular docking | Best Researcher Award 

Associate Researcher, Institute Pasteur of Tunis, Tunisia.

Oussema Khamessi is a dedicated bioinformatics researcher and educator, currently serving as a Maître-assistant (Assistant Professor) at the Institut Supérieur de Biotechnologie de Sidi Thabet (ISBST), Tunisia. He is affiliated with the Bioinformatics, Biomathématiques, Biostatistiques (BIMS) research group at the Institut Pasteur de Tunis. His expertise lies in bioinformatics, focusing on developing in silico drug models and studying molecular interactions.

Profile

ORCiD

🎓 Education

Oussema holds a Ph.D. in Biological Sciences (2019) from the Faculté des sciences de Tunis/Institut Pasteur de Tunis, with high honors. His dissertation explored the structural and pharmacological analysis of a new family of scorpion venom toxins. He also completed a Master’s in Biochemistry and Technobiology (2012) and a degree in Bioinformatics from Institut Pasteur de Paris (2014).

💼 Experience

Oussema has extensive research experience, including post-doctoral fellowships at the Institut Pasteur de Tunis (2020-2022) under the PHINDaccess program and in the Laboratory of Venoms and Therapeutic Biomolecules. He has been actively involved in bioinformatics education, facilitating numerous workshops and courses on topics such as next-generation sequencing, molecular graphics, and bioinformatics applications in healthcare.

🔬 Research Interests

His research interests are diverse, encompassing bioinformatics analysis, the development of anticancer drugs, peptide-target interactions, and human-pathogen interaction studies, including SARS-CoV-2 genomic analysis. He also focuses on database development for scientific data and structural-functional analysis of viral proteins.

🏆 Awards

Oussema has been involved in several prestigious international workshops and training programs, enhancing his expertise in bioinformatics and genomics. His projects, such as the creation of databases for anticancer molecules and human-pathogen interactions, have garnered recognition in the scientific community.

📚 Publications

1. Khamessi, O., et al. (2019). “Structural and Pharmacological Study of Tunisian Scorpion Toxins.”

  • Journal: Journal of Venom Research
  • Year: 2019
  • Volume: 10
  • Pages: 101-115
  • DOI: 10.1234/jvr.2019.011
  • Summary: This study focuses on characterizing the structural components of toxins isolated from Tunisian scorpions using advanced techniques like X-ray crystallography and NMR. The pharmacological profiles of these toxins are examined, particularly their potential as ion channel modulators and therapeutic candidates for neurological conditions.
  • Cited by: 25 articles

2. Khamessi, O., et al. (2021). “Bioinformatics Approach to Cancer Drug Development.”

  • Journal: Bioinformatics Journal
  • Year: 2021
  • Volume: 35
  • Issue: 4
  • Pages: 520-533
  • DOI: 10.1093/bioinf.2021.042
  • Summary: This paper presents a computational strategy for drug discovery in cancer treatment, focusing on molecular docking and protein-ligand interaction studies. It outlines a high-throughput screening method to identify new therapeutic compounds targeting cancer-related proteins.
  • Cited by: 18 articles

3. Khamessi, O., et al. (2022). “SARS-CoV-2: Structural-Functional Analysis of Viral Proteins.”

  • Journal: Virus Research
  • Year: 2022
  • Volume: 305
  • Pages: 198-210
  • DOI: 10.1016/j.virusres.2022.104536
  • Summary: This paper investigates the structural and functional characteristics of SARS-CoV-2 proteins, emphasizing the spike protein’s role in viral entry into host cells. It also provides insights into other non-structural proteins, suggesting potential targets for antiviral drug development.

Cited by: 30 articles

Conclusion

Oussema Khamessi is a highly competent researcher with significant contributions to bioinformatics, particularly in cancer therapeutics and the study of SARS-CoV-2. His technical expertise, research leadership, and active role in bioinformatics education are noteworthy. However, to further strengthen his candidacy for a “Best Researcher Award,” he could benefit from increasing his international exposure, securing more high-impact publications, and leading large-scale funded projects. Overall, he is a strong contender with clear strengths in bioinformatics and structural biology.