Mr . Partha Sarathi Nial | B-Z DNA transition | Best Researcher Award 

PhD Scholar , CSIR-Institute of Minerals and Materials Technology , India

Partha Sarathi Nial is a dedicated Ph.D. scholar in Biological Science at the CSIR-Institute of Minerals and Materials Technology, Bhubaneswar, India. His research focuses on DNA nanotechnology, specifically on sequence-specific conformational switching in linear and branched DNA structures. With a strong foundation in biotechnology and extensive experience in both academic research and industry, Partha is committed to advancing our understanding of DNA’s structural dynamics and their potential applications in gene regulation and therapeutics.

Profile

Scopus

Strengths for the Award

1. Advanced Research Focus: Partha Sarathi Nial’s doctoral research on “Sequence-specific conformational switching in linear and branched DNA structures” showcases a high level of expertise in a cutting-edge area of biological science, particularly in DNA nanotechnology and its applications in gene regulation and therapeutic approaches. His focus on B-Z DNA transition and G-Quadruplex formation is not only innovative but also highly relevant to understanding complex biological processes and diseases like cancer and Alzheimer’s.
2. Publications in High-Impact Journals: Partha has multiple publications in reputed journals with high impact factors, including the Journal of Molecular Liquids and the International Journal of Biological Macromolecules. These publications underline the quality and impact of his research work in the scientific community.
3. Awards and Recognitions: Partha’s achievements, such as securing the CSIR-NET JRF (AIR-100) in Life Sciences, demonstrate his strong academic foundation and recognition by peers. Being selected for positions in prestigious organizations like Thyrocare Technologies Ltd. further attests to his credibility and potential.
4. Research Versatility: Partha’s diverse research experience, ranging from clinical research coordination to plant tissue culture and drug analysis, shows his adaptability and broad expertise in various domains of biological science.
5. Professional Development: Participation in numerous seminars, workshops, and webinars, including poster presentations at international conferences, reflects his commitment to continuous learning and dissemination of knowledge.

Areas of Improvement

1. Practical Application Focus: While Partha’s research is highly theoretical and advanced, greater emphasis on practical applications and translational research might further strengthen his candidacy. This could involve exploring more collaborative projects with industry or interdisciplinary teams to apply his findings in real-world scenarios.
2. Leadership and Collaboration: Although Partha has demonstrated strong research capabilities, leadership roles in collaborative research projects or mentoring junior researchers could enhance his profile. Active involvement in large-scale, multi-disciplinary projects might also broaden his impact.
3. Broader Impact: Expanding the outreach and societal impact of his research beyond the academic community could be beneficial. Engaging in public science communication, community outreach, or contributing to policy discussions on health and biotechnology could elevate his profile.

    Education

   Partha Sarathi Nial’s academic journey is marked by consistent excellence in the field of biological sciences. He earned his Ph.D. in Biological Science from the CSIR-Institute of Minerals and Materials Technology, focusing on the intricate mechanisms of B-Z DNA transition and its implications in various human diseases. Before his doctoral studies, he completed his B.Ed. in Biological Science from Andhra University and both his M.Sc. and B.Sc. in Biotechnology from Ravenshaw University and Utkal University, respectively, graduating with first-division honors.

    Research Experience

   Partha’s research expertise is deeply rooted in the molecular dynamics of DNA structures. His doctoral research explores the B-Z DNA transition, G-Quadruplex formation, and the impact of Rare Earth Elements on DNA conformations. He has also contributed to projects on gene regulation, therapeutic applications, and DNA nanostructure assembly. His M.Sc. dissertation focused on the micropropagation of Uraria picta, and he has gained hands-on experience in biochemical and bacteriological analysis of dairy products, clinical research on diarrhea, and drug quality evaluation.

    Research Interests

   Partha’s research interests lie at the intersection of molecular biology, nanotechnology, and structural biophysics. He is particularly fascinated by the conformational switching of DNA structures, such as B-Z DNA transitions and G-quadruplex formations, which have significant implications in gene function regulation and nanotechnological applications. His work aims to uncover the underlying mechanisms of these transitions and explore their potential in medical and therapeutic innovations.

    Awards and Achievements

   Partha’s academic and research endeavors have been recognized with several prestigious awards. He secured the Junior Research Fellowship (CSIR-NET JRF) with an impressive All India Rank of 100 in Life Sciences in 2018. Additionally, he was selected as a Clinical Research Coordinator by Consortium Clinical Research Pvt Ltd. and as an Executive in Business Development by Thyrocare Technologies Ltd., showcasing his versatile expertise in both research and industry.

    Publications

   Partha Sarathi Nial has contributed to several high-impact publications in reputable scientific journals. Here are some of his key works:

   1. Nial, P. S., Sathyaseelan, C., Bhanjadeo, M. M., Tulsiyan, K. D., Rathinavelan, T., & Subudhi, U. (2024). Praseodymium chloride-mediated B-to-Z DNA transition in pyrimidine-purine repeat sequences: Simulation and biophysical study. Journal of Molecular Liquids, 125173. Link. Cited by: 5 articles.
   2. Nial, P. S., & Subudhi, U. (2024). Zeta potential of Z-DNA: A new signature to study BZ transition in linear and branched DNA. International Journal of Biological Macromolecules, 266, 131238. Link. Cited by: 3 articles.
   3. Satapathy, S. N., Nial, P. S., Tulsiyan, K. D., & Subudhi, U. (2024). Light rare earth elements stabilize G-quadruplex structure in variants of human telomeric sequences. International Journal of Biological Macromolecules, 254, 127703. Link. Cited by: 4 articles.
   4. Monalisa, K., Behera, S., Pidika, S. P., Nial, P. S., & Naik, S. K. (2024). In vitro propagation and assessment of genetic fidelity of Blepharispermum subsessile DC.: An endangered medicinal plant of India. Vegetos, 1-10. Link. Cited by: 2 articles.
   5. Baral, B., Nial, P. S., & Subudhi, U. (2023). Enhanced enzymatic activity and conformational stability of catalase in presence of tetrahedral DNA nanostructures: A biophysical and kinetic study. International Journal of Biological Macromolecules, 242, 124677. Link. Cited by: 6 articles.
   6. Gourai, M., Nayak, A. K., Nial, P. S., Satpathy, B., Bhuyan, R., Singh, S. K., & Subudhi, U. (2023). Thermal plasma processing of Moringa oleifera biochars: Adsorbents for fluoride removal from water. RSC Advances, 13(7), 4340-4350. Link. Cited by: 7 articles.
   7. Bhanjadeo, M. M., Nial, P. S., Sathyaseelan, C., Singh, A. K., Dutta, J., Rathinavelan, T., & Subudhi, U. (2022). Biophysical interaction between lanthanum chloride and (CG) n or (GC) n repeats: A reversible B-to-Z DNA transition. International Journal of Biological Macromolecules, 216, 698-709. Link. Cited by: 9 articles

   Conclusion

   Partha Sarathi Nial is a highly deserving candidate for the Research for Best Researcher Award. His strong research background in DNA nanotechnology, coupled with significant publications and recognitions, makes him a standout candidate. To further enhance his profile, focusing on practical applications, taking on leadership roles in collaborative research, and broadening the societal impact of his work are recommended. Overall, his current achievements and potential for future contributions to science make him a suitable and strong contender for the award.