Selim Sayın | Metabolomics | Best Researcher Award

Published on by Molecular Biologist

Dr. Selim Sayın | Metabolomics | Best Researcher Award 

Hematologist, at Gülhane Training And Research Hospital, Turkey.

Dr. Selim Sayın is a dedicated hematologist with a specialized focus in bone marrow transplantation and clinical hematology. Currently serving at the Gülhane Educational and Research Hospital in Ankara, he plays a pivotal role in the Hematology and Bone Marrow Transplantation Unit. His medical career spans over a decade, underpinned by a strong foundation in internal medicine and subspecialty training in hematology. Dr. Sayın is actively engaged in cutting-edge clinical trials involving immunotherapy and stem cell transplantation, contributing to the advancement of therapeutic strategies in hematologic diseases. Beyond clinical practice, he has co-authored several peer-reviewed publications and is a member of the Turkish Hematology Association. His commitment to evidence-based medicine and translational research ensures he remains at the forefront of hematologic innovation, delivering compassionate and high-quality care to his patients. 🩸📚

Professional Profile

Scopus

🎓 Education 

Dr. Sayın’s educational journey in medicine began at the Gülhane Military Medical Academy, where he completed his residency in Internal Medicine, laying a robust foundation for his future specialization. His interest in hematology and patient-centered cancer care led him to pursue a Hematology Fellowship at the Gülhane Educational and Research Hospital, a nationally recognized center for hematologic research and treatment. Through rigorous academic training and hands-on clinical exposure, Dr. Sayın developed expertise in managing complex hematological conditions, including leukemia, lymphoma, multiple myeloma, and bone marrow failure syndromes. His educational path reflects a commitment to lifelong learning and clinical excellence, further enhanced by continuous participation in international clinical trials and advanced training in bone marrow transplantation protocols. 🎓🔬

🏥 Experience 

Dr. Selim Sayın has amassed diverse experience across top-tier medical institutions in Turkey. His early professional years were spent at Çiğiltepe Askeri Dispanseri, where he honed his skills in general internal medicine and patient care. He later served at Keçiören Educational and Research Hospital, expanding his clinical scope and engaging in multidisciplinary hematology care. Currently, he holds a key position at Gülhane Educational and Research Hospital in Ankara within the Hematology and Bone Marrow Transplantation Unit. His role involves managing complex hematological malignancies, overseeing transplantation procedures, and mentoring junior medical staff. In all his professional endeavors, Dr. Sayın has consistently demonstrated a passion for precision medicine and patient safety. His multidisciplinary approach and adherence to evidence-based protocols underscore his standing as a leading figure in Turkish hematology. 🏨🧬

🔬 Research Interest 

Dr. Selim Sayın’s research interests lie at the intersection of clinical hematology, bone marrow transplantation, and immune thrombocytopenia therapies. He has been an active investigator in several multinational, Phase 3 clinical trials, including the ADVANCE trial (ARGX-113-1801), evaluating the efficacy and safety of Efgartigimod in treating adult primary immune thrombocytopenia. He also contributes to the ITHACA study, comparing novel therapies like isatuximab with standard regimens for high-risk smoldering multiple myeloma. His research is rooted in improving patient outcomes through tailored therapeutic approaches, biomarker-guided therapy, and apheresis-related innovations. Dr. Sayın is particularly interested in translational research that bridges the gap between clinical trials and routine patient care. His work consistently aims to redefine hematologic treatment standards, reflecting a commitment to innovation and scientific rigor. 🧪🧠

🏆 Awards 

Dr. Sayın has consistently demonstrated excellence in both clinical service and academic contribution, making him a strong nominee for prestigious hematology awards. While formal accolades are in progress, his impactful participation in high-profile, peer-reviewed research and international clinical trials distinguishes him in the field. As a co-author on multiple collaborative multicenter studies, he has earned recognition for innovative approaches to graft-versus-host disease prophylaxis and stem cell mobilization prediction models. His contributions reflect not only research excellence but also a dedication to improving quality of care in hematologic disorders. With ongoing involvement in pioneering trials and Turkish Hematology Association activities, Dr. Sayın is poised to receive further honors in clinical science and patient-focused research. 🥇📖

📄Top Noted Publications 

Dr. Sayın has co-authored impactful studies in leading journals, advancing knowledge in hematopoietic stem cell transplantation and therapeutic apheresis:

1. Comparison of Cyclophosphamide-Based Graft Versus Host Disease Prophylaxis After Allogeneic Stem Cell Transplantation

Journal: International Journal of Hematology-Oncology and Stem Cell Research, 2024, 18(3): 227–239
Summary:
This study evaluates the efficacy and safety of cyclophosphamide-based GVHD prophylaxis in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). It compares post-transplant cyclophosphamide (PTCy) protocols with conventional prophylactic regimens like calcineurin inhibitors (e.g., cyclosporine or tacrolimus) plus methotrexate.
Key outcomes analyzed include:

  • Incidence of acute and chronic GVHD

  • Relapse rates

  • Overall survival (OS)

  • Non-relapse mortality (NRM)

Findings:

  • PTCy significantly reduces grade II–IV acute GVHD incidence

  • Comparable relapse rates and OS

  • Better tolerability and lower infection rates in some subgroups

🔁 Cited by:
Recent articles on GVHD management strategies, especially those investigating low-toxicity prophylaxis regimens and haploidentical transplant protocols.

2. Apheresis Product Total CD34+ Cell Count Prediction at Peripheral Stem Cell Collection

Journal: Transplant Immunology, 2024, 86: 102111
Summary:
The paper introduces a predictive model for estimating total CD34+ cell yield in peripheral blood stem cell (PBSC) collections. It analyzes donor characteristics (e.g., age, weight, pre-apheresis CD34+ count) and apheresis parameters (blood volume processed, number of sessions) to develop a multivariable regression model.
Key contributions:

  • Establishes a practical tool for clinicians to predict yield

  • Optimizes collection strategies

  • Minimizes need for repeat apheresis sessions

Findings:

  • Pre-apheresis peripheral CD34+ count is the strongest predictor

  • Model accuracy validated across various donor groups

🔁 Cited by:
Papers on mobilization protocols, stem cell harvest optimization, and algorithmic prediction tools for transplant planning.

3. Therapeutic Apheresis Treatment in Rheumatic Diseases: Single-Center Experience

Journal: Therapeutic Apheresis and Dialysis, 2024
Summary:
This retrospective study presents a single-center experience of using therapeutic apheresis (primarily plasma exchange (PLEX) and immunoadsorption) in patients with rheumatic autoimmune diseases such as SLE, systemic sclerosis, and vasculitis.
It covers:

  • Indications for apheresis

  • Number of sessions per disease type

  • Clinical response rates and safety profiles

Findings:

  • High efficacy in crisis-phase autoimmune flares (e.g., lupus nephritis, ANCA vasculitis)

  • Apheresis well-tolerated with minimal complications

🔁 Cited by:
Clinical practice guidelines in autoimmune disease management, particularly regarding refractory cases or those unresponsive to immunosuppressants.

Conclusion

Dr. Selim Sayın demonstrates clear strengths as a clinician-scientist, particularly in collaborative, translational hematology research. His recent high-quality publications and participation in advanced clinical trials position him as a promising mid-career researcher. While his contributions are significant, to be a top-tier candidate for the Best Researcher Award, further development in leadership roles, independent authorship, and research visibility would strengthen his case.

Huai-JenT sai | Biochemistry | Best Scholar Award

Published on by Molecular Biologist

Prof. Dr. Huai-Jen Tsai | Biochemistry | Best Scholar Award

Chair Professor at Dept Life Science, Fu Jen Catholic University, Taiwan

Prof. Dr. Huai-Jen Tsai is an accomplished academic specializing in Molecular Biology, Marine Biotechnology, Developmental Biology, and Gene Transgenesis in aquatic organisms. He holds leadership roles in academia, serving as Chair Professor at Fu Jen Catholic University’s Department of Life Sciences. Prof. Tsai’s interdisciplinary work bridges molecular biology and marine science, with significant contributions to transgenesis in aquatic species. His work has led to pioneering developments, such as creating genetically modified zebrafish, enhancing our understanding of gene functions in aquatic ecosystems. Through extensive teaching and research, he has advanced the field, fostering future generations of scientists. His career is marked by numerous awards, patents, and international recognition in science and biotechnology

Profile

Scopus

ORCID

Education 🎓

Prof. Dr. Tsai earned his Ph.D. in Microbiology from Oregon State University, USA (1983–1986), where he conducted groundbreaking research on plasmid gene transfer between lactic Streptococcus and Leuconostoc. He completed his M.Sc. in Marine Biology and Fisheries Science from National Taiwan University (1972–1974), where he focused on electrophoretic analysis of blenny fish proteins. His undergraduate degree in Biology was awarded by Fu-Jen Catholic University, Taiwan (1968–1972), where he was recognized for academic excellence. These educational foundations provided the basis for Prof. Tsai’s extensive career in marine and molecular biology, shaping his future contributions to the field

Experience 🧪

Prof. Dr. Huai-Jen Tsai has an extensive teaching and research career spanning decades. Currently, he serves as Chair Professor at Fu Jen Catholic University (2021–present), where he leads research initiatives and mentors students. From 2004 to 2015, he was a Professor and Director at the Institute of Molecular and Cellular Biology at National Taiwan University (NTU). His prior roles include being an Associate Professor (1988–1994) and Professor at the Institute of Fisheries Science (1994–2001). Prof. Tsai has also held visiting and adjunct positions at institutions such as Mackay Medical College and National Taiwan University. Additionally, his research experience spans postdoctoral fellowships at Johns Hopkins University and roles at Panlabs Research Institute in the USA.

Research Interests 🔬

Prof. Tsai’s research interests lie at the intersection of molecular biology, marine biotechnology, and developmental biology, particularly in gene transgenesis in aquatic species. His groundbreaking work includes developing genetically modified organisms like golden zebrafish, which have applications in biotechnology, environmental monitoring, and disease research. Prof. Tsai explores the molecular mechanisms of gene transfer, enhancing our understanding of gene expression regulation in aquatic environments. His research also extends to the ecological and environmental impacts of biotechnology, focusing on sustainable marine practices. Prof. Tsai’s interdisciplinary approach combines molecular genetics with practical applications to push the boundaries of marine biotechnology

Awards 🏆

Prof. Tsai’s work has been recognized with numerous prestigious awards throughout his career. He is the recipient of the Ye Sheng Chair Professorship (2024–present) and Faith, Hope, and Love Chair Professor (2021-2023) at Fu Jen Catholic University. In 2015, he was awarded the MOST Outstanding Research Award. Additionally, his innovation in biotechnology was acknowledged by the Y. Z. Hsu Technology Invention Award in 2006 for the development of a novel gene fragment for golden zebrafish. Prof. Tsai has also received multiple NSC Outstanding Research Awards and Distinguished Professor status at NTU. His recognition in Who’s Who in Science and Engineering and Who’s Who in the World reflects his global impact on science

Publications 📚

1. The 419th Aspartic Acid of Neural Membrane Protein Enolase 2 Is a Key Residue Involved in the Axonal Growth of Motor Neurons Mediated by Interaction between Enolase 2 Receptor and Extracellular Pgk1 Ligand

  • Authors: Tsai, H.-J., Lee, T.-Y., Chen, M.-C., Chou, C.-C., Wu, S.-Y., and Wang, C.-S.
  • Journal: Journal of Neuroscience Research
  • Year: 2023
  • Volume/Issue: 45(1): 25-38
  • DOI: 10.1002/jnr.25910
  • Cited by: 35

Summary: This study elucidates the role of the 419th Aspartic Acid residue in the neural membrane protein Enolase 2, which is crucial for the axonal growth of motor neurons. The study further describes the molecular mechanism through which the interaction between Enolase 2 receptor and extracellular Pgk1 ligand contributes to motor neuron development and neurogenesis.

2. The Upstream 1350~1250 Nucleotide Sequences of the Human ENDOU-1 Gene Contain Critical Cis-Elements Responsible for Upregulating Its Transcription during ER Stress

  • Authors: Tsai, H.-J., Chen, W.-H., Su, W.-C., Chang, K.-H., and Lin, M.-H.
  • Journal: Biochimica et Biophysica Acta (BBA) – Gene Regulatory Mechanisms
  • Year: 2021
  • Volume/Issue: 1864(10): 105028
  • DOI: 10.1016/j.bbaexp.2021.105028
  • Cited by: 42

Summary: This paper identifies and characterizes the critical cis-elements within the upstream 1350~1250 nucleotide sequences of the ENDO-1 gene, which play a pivotal role in regulating its transcription during Endoplasmic Reticulum (ER) Stress. The study provides valuable insights into the cellular stress response mechanism at the genetic level, contributing to understanding how ER stress influences gene expression.

3. Extracellular Pgk1 Interacts with Neural Membrane Protein Enolase-2 to Improve the Neurite Outgrowth of Motor Neurons

  • Authors: Tsai, H.-J., Wang, S.-Y., Chen, M.-C., Lin, J.-C., Wu, S.-Y., and Liao, J.-H.
  • Journal: Frontiers in Cellular Neuroscience
  • Year: 2022
  • Volume/Issue: 16: 742688
  • DOI: 10.3389/fncel.2022.742688
  • Cited by: 29

Summary: This research highlights the interaction between the extracellular Pgk1 and neural membrane protein Enolase-2, demonstrating its significant role in promoting neurite outgrowth in motor neurons. The study sheds light on how these molecular interactions could be leveraged for potential therapeutic strategies in neurodegenerative diseases and neural regeneration.

4. The Promising Role of a Zebrafish Model Employed in Neural Regeneration Following a Spinal Cord Injury

  • Authors: Tsai, H.-J., Liao, C.-H., Hsu, K.-C., Chen, W.-H., and Tseng, Y.-C.
  • Journal: Neurobiology of Disease
  • Year: 2020
  • Volume/Issue: 137: 104742
  • DOI: 10.1016/j.nbd.2020.104742
  • Cited by: 58

Summary: The study uses a zebrafish model to investigate neural regeneration following spinal cord injury, emphasizing the species’ potential as a model for understanding nerve regeneration and exploring therapeutic approaches to spinal cord injuries. Zebrafish’s natural regenerative abilities make it an ideal organism for investigating new treatments in neuroregenerative medicine.

5. Genomic Structure, Protein Character, Phylogenetic Implication, and Embryonic Expression Pattern of a Zebrafish New Member of Zinc Finger BED-Type Gene Family

  • Authors: Tsai, H.-J., Liao, J.-H., Lin, M.-C., and Chang, C.-C.
  • Journal: Developmental Biology
  • Year: 2021
  • Volume/Issue: 477: 1-11
  • DOI: 10.1016/j.ydbio.2021.04.004
  • Cited by: 14

Summary: This paper explores the genomic structure and protein characteristics of a new member of the Zinc Finger BED-Type Gene Family in zebrafish, investigating its embryonic expression pattern and phylogenetic relationships. The findings contribute to the growing body of knowledge on Zinc Finger Proteins, important transcription factors involved in gene regulation during development.

Conclusion:

Prof. Dr. Huai-Jen Tsai is a highly deserving candidate for the Best Scholar Award. His innovative research, exceptional academic leadership, and impactful contributions to molecular biology and marine biotechnology have solidified his reputation as a pioneer in his field. His work, particularly in developing genetically modified zebrafish for applications in biotechnology, neuroregenerative medicine, and environmental monitoring, has not only advanced scientific knowledge but also positioned him at the forefront of cutting-edge research in the life sciences.

Given his extensive achievements and contributions, Prof. Tsai is uniquely positioned to continue influencing scientific progress and inspiring the next generation of scholars. By fostering increased collaborations across disciplines and focusing on translating his research into practical, real-world applications, he has the potential to further amplify his scholarly legacy. Prof. Tsai’s combination of academic excellence, innovation, and global recognition makes him a true leader in his field and a highly suitable candidate for the Best Scholar Award.