Essa M. Saied | Molecular Biology | Research Excellence Award

Published on by Molecular Biologist

Assoc. Prof. Dr. Essa M. Saied | Molecular Biology | Research Excellence Award 

Associate Professor | Humboldt University of Berlin | Germany

Associate Prof. Dr. Essa M. Saied is a distinguished biochemist and bioorganic chemist whose work advances synthetic medicinal chemistry, lipid biochemistry, and small-molecule drug discovery. Holding research appointments at Humboldt University of Berlin and Suez Canal University, he has built an international reputation through 72 published documents, 2,232 citations from 1,538 citing sources, and an h-index of 31. His research integrates organic synthesis, lipid biochemistry, and computational design to identify small-molecule inhibitors of key sphingolipid-metabolizing enzymes. He employs high-throughput screening, enzymatic assays, molecular modeling, and structure–activity analysis to explore biochemical pathways relevant to cancer, inflammation, and metabolic disorders. His work also develops heterocyclic scaffolds, fluorescent probes, and biochemical tools that deepen understanding of lipid signaling and enzyme function. Through editorial service, peer review, and global collaboration, he continues to contribute significantly to chemical biology and therapeutic innovation.

Profiles: Scopus | ORCID| Google Scholar

Featured Publications

Live-Cell Identification of CERT Inhibitors via NanoBRET. Angewandte Chemie, Impact Factor 16.1.

Small-Molecule Ceramidase Inhibitors: Mechanism of Action. Angewandte Chemie, Impact Factor 16.8.

Stereoselective Synthesis of Novel Sphingoid Bases. International Journal of Molecular Sciences, Impact Factor 6.21.

Subunit Composition of Serine-Palmitoyltransferase. Proceedings of the National Academy of Sciences (PNAS), Impact Factor 11.2.

Resolving Sphingolipid Isomers Using Cryogenic IR Spectroscopy. Angewandte Chemie, Impact Factor 15.3.

Georges Nemer | Molecular Biology | Editorial Board Member

Published on by Molecular Biologist

Prof. Georges Nemer | Molecular Biology | Editorial Board Member 

Professor | Hamad Bin Khalifa University | Qatar

Dr. Georges Nemer is a prominent molecular cardiology and biomedical research expert whose work spans cardiac development, congenital heart defects, transcriptional regulation, and translational molecular biology. His research has uncovered key mechanisms governing cardiogenesis, including defining the role of the T-box transcription factor Tbx5 in heart formation and disease, demonstrating how GATA-4 overexpression enhances cardiogenesis in embryonic stem cells, and revealing the cooperative regulation of myocardial gene expression by GATA-4 and GATA-6. Dr. Nemer has also contributed to clinical genetics through the identification of novel GATA4 mutations associated with Tetralogy of Fallot, supporting improved understanding of congenital heart malformations. Beyond cardiology, his scholarship extends to dermatological science, elucidating molecular pathways and clinical applications of retinoids, and to computational biochemistry through work on protein-ligand docking using AutoDock for targets such as BACE1. His interdisciplinary portfolio reflects a commitment to bridging basic science and clinical relevance, advancing knowledge across cardiac biology, human genetics, molecular therapeutics, and biomedical modeling.

Profile: Google Scholar

Featured Publications

Bruneau, B. G., Nemer, G., Schmitt, J. P., Charron, F., Robitaille, L., Caron, S., …
(2001). A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease. Cell, 106(6), 709–721.

Grépin, C., Nemer, G., & Nemer, M. (1997). Enhanced cardiogenesis in embryonic stem cells overexpressing the GATA-4 transcription factor. Development, 124(12), 2387–2395.

Charron, F., Paradis, P., Bronchain, O., Nemer, G., & Nemer, M. (1999). Cooperative interaction between GATA-4 and GATA-6 regulates myocardial gene expression. Molecular and Cellular Biology, 19(6), 4355–4365.

Khalil, S., Bardawil, T., Stephan, C., Darwiche, N., Abbas, O., Kibbi, A. G., …
(2017). Retinoids: A journey from the molecular structures and mechanisms of action to clinical uses in dermatology and adverse effects. Journal of Dermatological Treatment, 28(8), 684–696.

Nemer, G., Fadlalah, F., Usta, J., Nemer, M., Dbaibo, G., Obeid, M., & Bitar, F. (2006). A novel mutation in the GATA4 gene in patients with Tetralogy of Fallot. Human Mutation, 27(3), 293–294.

El-Hachem, N., Haibe-Kains, B., Khalil, A., Kobeissy, F. H., & Nemer, G. (Year unavailable). AutoDock and AutoDockTools for protein-ligand docking: Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) as a case study. Neuroproteomics: Methods and Protocols, 391–403.