Attending physician and associate professor, at Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210093, China.
Dr. Guoyin Liu is an accomplished attending physician and associate professor at Jinling Hospital, Nanjing University, renowned for his expertise in orthopedics, inflammatory signaling, and regenerative medicine. Holding a PhD from Nanjing Medical University, he specializes in endoplasmic reticulum (ER) molecular chaperones such as GRP78/Bip and their role in critical orthopedic conditions including rheumatoid arthritis, osteoarthritis, chronic wounds, and periprosthetic osteolysis. Beyond molecular research, he pioneers innovative treatments like extracorporeal shock wave therapy, needle-knife therapy, and restorative laminoplasty techniques for spinal reconstruction. His translational research bridges basic science with clinical applications, contributing to novel interventions for musculoskeletal disorders. With an impressive portfolio of high-impact publications, key research grants, patents, and editorial board memberships, Dr. Liu exemplifies a commitment to advancing orthopedic science and patient care. His innovative contributions continue to shape the future of orthopedic diagnostics and treatments, fostering breakthroughs in bone regeneration and inflammatory disease management.
Professional Profile
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🎓 Education
Dr. Liu completed his PhD at Nanjing Medical University, focusing on the molecular mechanisms underlying inflammatory bone loss and tissue degeneration. His academic foundation integrates basic medical sciences, clinical orthopedics, and bioengineering approaches, enabling him to investigate complex orthopedic diseases at the cellular and molecular levels. During his training, he mastered advanced experimental techniques, including finite element biomechanical analysis, tissue engineering methodologies, and translational clinical trials. Dr. Liu expanded his academic horizon through specialized workshops in regenerative medicine, musculoskeletal biomechanics, and immunomodulation therapies. His education laid the groundwork for his pioneering research on GRP78/Bip signaling pathways in chronic musculoskeletal diseases. By blending clinical insights with experimental rigor, he has become a leading voice in developing innovative therapies for orthopedic patients. His educational journey reflects a seamless integration of theory and practice, empowering him to address both clinical challenges and fundamental biomedical questions with cutting-edge research approaches.
💼 Experience
With over 15 years of combined clinical and research experience, Dr. Guoyin Liu has established himself as a leading expert in orthopedic surgery, translational research, and regenerative medicine. As an Attending Physician and Associate Professor at Jinling Hospital, he manages complex cases such as spinal deformities, chronic joint diseases, and osteolytic conditions. His academic tenure includes supervising multidisciplinary research projects funded by National Natural Science Foundation of China and provincial grants focusing on inflammatory pathways and bone regeneration. He has innovated surgical techniques like restorative laminoplasty with miniplate fixation, which has improved postoperative spinal stability and patient recovery outcomes. His extensive clinical experience is complemented by editorial board appointments in reputed international journals, reflecting his scientific leadership. Dr. Liu’s dual role as a clinician and researcher enables him to directly translate benchside discoveries into bedside applications, ensuring tangible benefits for patients suffering from chronic orthopedic disorders.
🔬 Research Interests
Dr. Liu’s research is centered on cellular stress responses and inflammatory pathways in orthopedic diseases, with a special focus on endoplasmic reticulum molecular chaperones (GRP78/Bip) and their dual intracellular and extracellular roles. He investigates how particle-induced osteolysis, rheumatoid arthritis, and intervertebral disc degeneration are driven by inflammatory cascades, aiming to develop targeted molecular therapies. Another significant area of his research explores chemical chaperones like 4-Phenylbutyrate, which mitigate ER stress and improve bone regeneration. Dr. Liu also advances biomechanical engineering solutions, analyzing finite element models to improve spinal fixation techniques. Additionally, he integrates shockwave therapy, corticosteroid injections, and minimally invasive interventions for managing chronic orthopedic pain. His translational approach bridges basic science, bioengineering, and clinical orthopedics, leading to innovative strategies that reduce surgical complications and improve musculoskeletal repair. Through his research, Dr. Liu aims to redefine the diagnosis, prevention, and treatment of bone and joint diseases in aging populations.
🏆 Awards & Honors
Dr. Liu has received numerous academic and clinical recognitions for his groundbreaking work in orthopedics. He was honored with the Third Prize for Military Science & Technology Progress for elucidating the TIM3 signaling pathway in osteoarthritis during military training-related injuries. Additionally, he received the Third Award for Nanjing Science & Technology Progress for identifying the role of recombinant BMP-1 in periprosthetic osteolysis. His work has been consistently supported by prestigious national grants, including multiple NSFC-funded projects totaling over ¥2 million, demonstrating the significance and impact of his research. Beyond awards, his appointment to editorial boards of leading orthopedic and bioengineering journals highlights his global recognition in the field. Dr. Liu’s innovative surgical methods, such as restorative laminoplasty with H-shaped miniplates, have been acknowledged as transformative in spinal reconstruction. These accolades collectively recognize his outstanding contribution to orthopedic research, surgical innovation, and patient care.
📚 Top Noted Publications
Dr. Liu’s publications span orthopedic biomechanics, inflammatory pathways, and regenerative medicine, widely cited in the global research community. Key works include:
🛠️ Biomechanical Stability of Miniplates in Restorative Laminoplasty
Title: Comparative Biomechanical Stability of the Fixation of Different Miniplates in Restorative Laminoplasty after Laminectomy: A Finite Element Study
Authors: Guoyin Liu, Weiqian Huang, Nannan Leng, Peng He, Xin Li, Muliang Lin, Zhonghua Lian, Yong Wang, Jianmin Chen, Weihua Cai
Journal: Bioengineering (Basel)
Year / Volume / Issue: 2024; 11(5):519
DOI: 10.3390/bioengineering11050519 PubMed+15MDPI+15ResearchGate+15
Highlights: Used a finite element model (L2–L4) to compare H‑shaped, L‑shaped, and two‑hole miniplates. The H‑shaped design showed superior stability, especially in axial rotation and flexion/extension PubMedMDPI.
Biomechanical Reconstruction of the Posterior Complex in Laminoplasty
Title: Biomechanical evaluation of reconstruction of the posterior complex in restorative laminoplasty with miniplates
Authors: Jianmin Chen, Guoyin Liu, Tianyi Bao, Yuansheng Xu, Hu Luo, Yu Wu, Dawei Cai, Feng Qin, Jianning Zhao
Journal: BMC Musculoskeletal Disorders
Year / Volume / Article: 2023; 24(1):298
DOI: 10.1186/s12891-023-06380-3 PubMedOUCI
Highlights: Cadaveric 3D-printed L4 models under static/dynamic loading. H‑shaped miniplates outperformed L‑shaped and two-hole systems, preventing lamina collapse or plate breakage PubMedResearchGate.
Macrophage Apoptosis Pathways in Periprosthetic Osteolysis
Title: Apoptotic pathways of macrophages within osteolytic interface membrane in periprosthetic osteolysis
Journal: APMIS
Year: 2017
Details: Demonstrates that wear particles at implant interfaces accelerate macrophage apoptosis via ER-stress and mitochondrial dysfunction, which exacerbates osteolysis PubMedPhysiology Journals.
Endoplasmic Reticulum Stress and Osteolysis
Title: Endoplasmic reticulum stress-mediated inflammatory signaling pathways within the osteolytic periosteum and interface membrane in particle-induced osteolysis
Authors: Guoyin Liu, Naicheng Liu, Yuansheng Xu, Yunfan Ti, Jiangning Chen, Jianmin Chen, Junfeng Zhang, Jianning Zhao
Journal: Cell and Tissue Research
Year / Issue / Pages: 2016 Feb; 363(2):427–447
DOI: 10.1007/s00441-015-2205-9 PubMedSpringerLink
Highlights: Particle debris induces ER stress in macrophages, triggering IRE1α, GRP78/BiP, NF‑κB pathways, elevating pro-inflammatory cytokines (TNF‑α, IL‑1β, IL‑6). 4‑PBA effectively reduced ER-stress and osteolysis in murine models .
Conclusion
Dr. Guoyin Liu’s outstanding contributions to orthopedic research, innovative therapies, and patented medical devices make him a highly suitable candidate for the Best Researcher Award. His work bridges basic molecular research with clinical applications, significantly improving diagnosis, treatment, and rehabilitation of complex musculoskeletal disorders.