Senior Principal Scientist, at CSIR-Central Drug Research Institute, India.
Dr. Prem N. Yadav is a distinguished neuroscientist and pharmacologist specializing in opioid receptor modulation, neuropharmacology, and drug discovery. Currently serving as a Senior Principal Scientist & Head at the Division of Neuroscience & Ageing Biology, CSIR-CDRI, he has made significant contributions to neuropsychiatric disorder research. His work spans molecular pharmacology, receptor biology, and translational neuroscience. With extensive postdoctoral research experience in the USA, Dr. Yadav has played a pivotal role in advancing pharmacological interventions for mental health disorders. He is a recipient of prestigious awards, including the Ramanujan Fellowship, and has published extensively in high-impact journals. 📚🔬
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Education 🎓
Dr. Yadav holds a Ph.D. in Immunopharmacology from SGPGIMS, Lucknow (2002) and an M.Sc. in Biochemistry from Lucknow University (1996). His academic foundation in immunopharmacology and biochemistry has shaped his research in neuropharmacology, particularly in understanding receptor mechanisms and developing therapeutic strategies for neurological disorders. His interdisciplinary expertise bridges molecular biology and pharmacological innovation.
Experience 👨🔬
Dr. Yadav has over two decades of experience in pharmacology and neuroscience. He has held significant research positions, including:
- Senior Principal Scientist & Head (2021-Present) at CSIR-CDRI’s Neuroscience & Ageing Biology Division.
- Principal Scientist (2016-2021) at CSIR-CDRI, leading groundbreaking studies on opioid receptors.
- Research Associate (2007-2011) at the University of North Carolina, focusing on neuropharmacological mechanisms.
- Post-Doctoral Fellow (2002-2007) at New Jersey Medical School, contributing to receptor biology research. His work continues to impact neuropsychiatric drug development and receptor-targeted therapies.
Research Interests 🔍
Dr. Yadav’s research focuses on opioid receptor pharmacology, drug discovery, and neuropsychiatric disorders. His studies explore GPCR signaling, receptor modulation, and epigenetic mechanisms in depression. He aims to develop novel therapeutics for neurodegenerative diseases and psychiatric conditions by leveraging pharmacological and biochemical insights. His contributions include pioneering research on kappa-opioid receptors, serotonin receptor modulators, and neuroplasticity mechanisms.
Awards 🏆
Dr. Yadav has received numerous accolades for his contributions to neuroscience and pharmacology, including:
- Ramanujan Fellowship (2012-2017) – Supporting independent research careers for distinguished scientists.
- Young Scientist Award (2010) – Recognized by the Serotonin Club, Montreal, Canada.
- Travel Award (2006) – For presenting research at the International Narcotic Research Conference, St. Paul, MN. These honors highlight his influence in pharmacology and neuroscience.
Top Noted Publications 📖
Dr. Yadav has authored over 60 high-impact publications in prestigious journals. Notable works include:
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“Kappa Opioid Receptor Activation Induces Epigenetic Silencing of Brain-Derived Neurotropic Factor via HDAC5 in Depression.” Published in ACS Chemical Neuroscience, August 2024.
Authors: Anubhav Yadav, Shalini Dogra, Arun Kumar Boda, Poonam Kumari, Ajeet Kumar, M. Dash, and Prem N. Yadav.
Summary: This study explores the role of central kappa opioid receptor (KOR) activation in depression. The researchers found that sustained KOR activation leads to depression-like symptoms in mice by epigenetically silencing brain-derived neurotrophic factor (BDNF) expression in the prefrontal cortex via HDAC5. These findings provide insights into how KOR activation contributes to major depressive disorders.
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“Discovery and Structure–Activity Relationships of 2,4,5-Trimethoxyphenyl Pyrimidine Derivatives as Selective D5 Receptor Partial Agonists.” Published in Bioorganic Chemistry, September 2024.
Authors: Sakesh Kumar, Sumit K. Rastogi, Subrata Roy, Kajal Sharma, Santosh Kumar, Debalina Maity, Diwan Chand, Sachin Vishwakarma, Jiaur Gayen, Kinshuk Raj Srivastava, Ravindra Kumar, and P. N. Yadav.
Summary: The researchers designed and synthesized forty non-catecholamine-based pyrimidine derivatives and identified four as selective D5 receptor partial agonists. Among them, compound 5c (4-(4-bromophenyl)-6-(2,4,5-trimethoxyphenyl)pyrimidin-2-amine) exhibited modest D5 receptor agonist activity, as demonstrated using a cAMP-based GloSensor assay in HEK293T cells.
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“Baicalein Isolated from Oroxylum Indicum Acts as a Potent µ- and κ-Opioid Receptor Antagonist.” Published in Natural Product Research, 2024.
Authors: Information not available from the provided sources.
Summary: Specific details about this study are not available in the provided sources.
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“Molecular Mechanism of Distinct Chemokine Engagement and Functional Divergence of the Human Duffy Antigen Receptor.” Published in Cell, 2023.
Authors: Information not available from the provided sources.
Summary: Specific details about this study are not available in the provided sources.
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“An Amide to Thioamide Substitution Improves the Permeability and Bioavailability of Macrocyclic Peptides.” Published in Nature Communications, 2023.
Authors: Information not available from the provided sources.
Summary: Specific details about this study are not available in the provided sources.
Conclusion
Dr. Prem N. Yadav is a highly accomplished scientist with significant contributions to neuropharmacology, opioid receptor research, and medicinal chemistry. His leadership at CSIR-CDRI, prestigious fellowships, and impactful publications make him an excellent candidate for the Best Researcher Award. Strengthening industry collaborations, patent filings, and national awards would further elevate his credentials.