Jan Tesarik | Molecular Diagnostics | Excellence in Research

Published on by Molecular Biologist

Dr. Jan Tesarik | Molecular Diagnostics | Excellence in Research 

Dr. Jan Tesarik is a renowned Czech reproductive endocrinologist and embryologist, celebrated for his groundbreaking contributions to assisted reproductive technologies. He achieved the world’s first successful Gamete Intra-Fallopian Transfer (GIFT) in 1982, and later pioneered the first childbirths following oocyte fertilization with round spermatids (ROSI) and in-vitro cultured elongating spermatids (ELSI) in 1995 and 1998, respectively. In 2000, he developed an innovative nuclear transfer technique in mature human oocytes, now popularly known as the “3-parent-baby technique.” Dr. Tesarik has also advanced virtual imaging endoscopy methods and explored the beneficial effects of growth hormone on oocyte quality and uterine receptivity. Currently, he serves as the Director of the MARGen Clinic in Granada, Spain, and holds editorial positions in several esteemed journals. With over 400 scientific publications and more than 18,000 citations, his work continues to shape the field of reproductive medicine. researchgate.net

Professional Profile

Scopus

🎓 Education 

Dr. Tesarik obtained his MD degree in 1979 and his PhD in 1982 from the University of Prague. His early academic pursuits laid a strong foundation in reproductive biology, leading him to explore innovative techniques in human reproduction. His doctoral research focused on gamete physiology and early embryonic development, areas that would become central to his future breakthroughs. Throughout his academic journey, Dr. Tesarik demonstrated a commitment to integrating clinical practice with cutting-edge research, a philosophy that has guided his illustrious career.

💼 Experience 

Dr. Tesarik’s professional journey spans several decades and continents. After completing his education, he worked at Purkyne University in Brno, Czechoslovakia, where he began his pioneering research in reproductive medicine. In 1989, he joined the American Hospital of Paris, contributing to significant advancements in assisted reproductive technologies. Currently, he is the Director of the MARGen Clinic in Granada, Spain, where he continues to lead innovative research and clinical practices in reproductive health. His international experience has enriched his perspective, allowing him to integrate diverse methodologies and cultural approaches into his work.

🔬 Research Interests 

Dr. Tesarik’s research interests are deeply rooted in reproductive biology and embryology. He has extensively studied gamete physiology, fertilization processes, and early embryonic development. His work on the application of growth hormone in improving oocyte quality and uterine receptivity has opened new avenues in fertility treatments. Additionally, he has developed virtual imaging techniques, such as virtual hysteroscopy and salpingoscopy, enhancing non-invasive diagnostic capabilities in gynecology. In response to the COVID-19 pandemic, Dr. Tesarik investigated the effects of the virus on fertility and explored potential protective agents, including melatonin, to safeguard reproductive health during infections. researchgate.net

🏆 Awards 

Dr. Tesarik’s contributions to reproductive medicine have been recognized globally. Notably, he received the Silver Prize Award at the 1st International Congress of Perinatal Medicine in Tokyo, Japan, for his research on reproductive risks associated with consecutive abortions. His innovative techniques and clinical applications have earned him accolades from various medical societies and institutions. Beyond formal awards, his appointment as an Associate Editor in journals like Frontiers in Endocrinology and International Journal of Molecular Sciences reflects the high esteem in which his peers hold him. These honors underscore his enduring impact on the field of reproductive health.ecronicon.net

📚 Top Noted Publications 

Dr. Tesarik has an extensive publication record, with over 400 scientific articles and book chapters to his name. His works are widely cited, reflecting their significance in the field. Some of his notable publications include:

1. Endocrinology of Primary Ovarian Insufficiency: Diagnostic and Therapeutic Clues (2025)

This article provides a comprehensive overview of Primary Ovarian Insufficiency (POI), discussing its endocrinological aspects, diagnostic challenges, and potential therapeutic approaches. It emphasizes the importance of early detection and individualized treatment strategies to manage POI effectively.

2. Editorial: Growth Hormone in Fertility and Infertility: Physiology, Pathology, Diagnosis and Treatment, Volume II (2024)

This editorial summarizes recent findings on the role of growth hormone (GH) in female fertility and infertility. It discusses GH’s mechanisms of action in the reproductive system and explores its therapeutic potential in enhancing fertility outcomes, particularly in assisted reproductive technologies. frontiersin.org+2frontiersin.org+2researchgate.net+2

3. Mitochondria in Human Fertility and Infertility (2023)

Conclusion

Dr. Jan Tesarik’s career reflects exceptional innovation, longevity, and global impact in reproductive medicine and related biomedical sciences. His pioneering procedures (GIFT, ROSI, ELSI, nuclear transfer) and diagnostic tools place him among the leading figures in the field. While there is room to highlight collaborative and funding leadership more explicitly, the depth, originality, and translational success of his work strongly support his candidacy for a Research for Excellence Award.

Anam Ashraf | Structural Biology | Women Researcher Award

Published on by Molecular Biologist

Dr. Anam Ashraf | Structural Biology | Women Researcher Award 

DHR Young Scientist, at Jamia Millia Islamia, India.

Dr. Anam Ashraf is a dynamic and accomplished researcher with a Ph.D. in Life Sciences, specializing in molecular and structural biology, drug discovery, and research communication. Her scholarly journey spans prestigious institutions like the National Institute of Immunology and Jamia Millia Islamia. With a flair for both benchwork and penwork, Dr. Ashraf excels in scientific writing, grant proposals, and research translation. She has significantly contributed to the understanding of pathogen biology, cancer therapeutics, and microbial resistance. Her collaborative projects and high-impact publications reflect her innovative mindset and interdisciplinary approach. As a co-corresponding author on multiple articles, she demonstrates leadership and scientific clarity. Dr. Ashraf continues to bridge the gap between complex molecular mechanisms and translational science, aspiring to channel her research acumen into impactful scientific writing and policy communication. She brings passion, precision, and purpose to every project she undertakes. 📚💡

Professional Profile

Scopus

ORCID

🎓 Education

Dr. Anam Ashraf’s academic foundation is rooted in premier Indian institutions, beginning with a Bachelor’s in Biotechnology from Jamia Millia Islamia (2010–2013), where she cultivated her interest in molecular biology. She then pursued an M.Sc. in Biotechnology from South Asian University (2013–2015), engaging in research on microRNA-181a and its role in liver fibrosis. Her scholarly trajectory culminated in a Ph.D. from the National Institute of Immunology (2015–2021), focusing on the mechanistic properties of the enzyme HisI and histidine biosynthesis dynamics in Mycobacterium tuberculosis. During her doctoral research, Dr. Ashraf developed deep expertise in structural biology, molecular dynamics, and host-pathogen interactions. Her academic record is complemented by her qualification of the highly competitive DBT-JRF (Category I) national-level examination in 2015. Each stage of her education has honed her analytical thinking, experimental rigour, and communication skills, making her a standout scholar in the life sciences domain. 🎓🔬

🧪 Experience

Dr. Anam Ashraf’s professional journey reflects over a decade of laboratory and academic excellence. Currently serving as a DHR-Young Scientist at Jamia Millia Islamia (since September 2022), she previously held a Senior Research Fellowship (SRF) there from 2021 to 2022. Her experience encompasses structural analysis of enzymes, inhibitor screening, and molecular dynamics simulations. Dr. Ashraf’s diverse skill set includes scientific manuscript writing, bioinformatics, grant proposal development, and public speaking. She has played key roles in multiple interdisciplinary research teams, contributing as both experimentalist and co-corresponding author. Her collaborative work spans microbiology, oncology, and computational biology, positioning her at the forefront of translational biomedical research. Dr. Ashraf’s research outputs have been presented at leading global forums and published in prestigious journals. Her combination of scientific depth and communicative clarity makes her uniquely qualified for both research-intensive and science communication roles. 🧫🧠

🔍 Research Interests

Dr. Anam Ashraf’s research interests lie at the confluence of molecular biology, structural biology, and computational drug discovery. Her doctoral work on Mycobacterium tuberculosis explored enzyme dynamics in host infection contexts, laying a foundation for antimicrobial development. Passionate about solving real-world biomedical challenges, she actively explores oxidative stress pathways, transcriptional regulation in pathogens, and cancer therapeutics via natural compound screening. She is particularly interested in structure-guided drug design, using techniques like X-ray crystallography, molecular docking, and MD simulations. Her recent focus on targeting proteins like RfaH and Aurora Kinase B with plant-derived compounds reflects a translational vision for therapy. Additionally, Dr. Ashraf is intrigued by the gut-brain axis, microbial endocrinology, and the interface between microbiota and host metabolism. Her interdisciplinary expertise empowers her to dissect complex mechanisms and identify novel therapeutic targets. Her work exemplifies how basic science can fuel next-generation treatment strategies. 🔬💊🧠

🏆 Awards

Dr. Anam Ashraf has garnered numerous accolades throughout her academic and research career. She qualified for the prestigious DBT-JRF Category I examination in 2015, which supported her doctoral research at the National Institute of Immunology. Her oral and poster presentations have been recognized at both national and international platforms, including the AsCA 2024 Conference in Malaysia, Keystone Symposia in the USA, and INCD 2023 in Chandigarh, where her innovative work on antimicrobial and cancer therapeutics was spotlighted. Her selection as a DHR-Young Scientist further reflects the national recognition of her scientific contributions. Dr. Ashraf’s ability to distill complex research into accessible formats has also earned her commendation in interdisciplinary forums such as “Global Bio-India” and “Biophysika.” Her consistent presence at high-impact events demonstrates not only her scientific merit but also her commitment to disseminating knowledge across academia and industry. 🥇📢

📚Top Noted Publications

Dr. Anam Ashraf has published extensively in high-impact journals, with over 19 peer-reviewed articles, several as co-corresponding or equal author. Her publications span antimicrobial research, structural biology, oncology, and microbial endocrinology.

🔬 Structural Biology & Enzymology

  1. Crystal Structure of Thymidine Kinase

    • Authors: [Authors not specified]

    • Journal: BBA – Proteins and Proteomics

    • Year: 2025

    • Citations: 5+

    • DOI: [DOI not available]PubMed+6PubMed+6Frontiers+6PubMed+11PubMed+11Directory of Open Access Journals – DOAJ+11

  2. Structure-Guided Identification of MTH1 Inhibitors

    • Authors: [Authors not specified]

    • Journal: Chemical Papers

    • Year: 2025

    • Citations: 3

    • DOI: [DOI not available]

  3. PDB Structure Submission

    • PDB ID: 8Y7W

    • Year: 2024

    • Details: Structural data from a protein crystallography study

    • Link: RCSB PDB Entry

  4. Conformational Switch in PIM-1

    • Authors: [Authors not specified]

    • Journal: Computational Biology and Chemistry

    • Year: 2024

    • Citations: 2

    • DOI: [DOI not available]PubMed+6PubMed+6Frontiers+6Frontiers+10PubMed+10PubMed+10

  5. Effect of pH on TK Enzyme

    • Authors: [Authors not specified]

    • Journal: Journal of Biomolecular Structure and Dynamics

    • Year: 2023

    • DOI: [DOI not available]

🧬 Molecular Mechanisms & Disease Links

  1. Role of MTH1 in Oxidative Stress and Therapeutic Targeting of Cancer

    • Authors: [Authors not specified]

    • Journal: Redox Biology

    • Year: 2024

    • Citations: 4

    • DOI: 10.1016/j.redox.2024.103394ScienceDirect

  2. Microbial Endocrinology and Metabolism

    • Authors: [Authors not specified]

    • Journal: Molecular and Cellular Endocrinology

    • Year: 2024

    • Citations: 1

    • DOI: [DOI not available]PubMed+9PubMed+9ResearchGate+9Frontiers+4PubMed+4SpringerLink+4

  3. Targeting Transcriptional Regulatory Protein RfaH with Natural Compounds to Develop Novel Therapies Against Klebsiella pneumoniae

    • Authors: Anam Ashraf, Arunabh Choudhary, Mohammad Ali Khan, Saba Noor, Afzal Hussain, Mohamed F. Alajmi, Md Imtaiyaz Hassan

    • Journal: Journal of Biomolecular Structure and Dynamics

    • Year: 2024

    • DOI: 10.1080/07391102.2024.2427376Taylor & Francis Online+1ResearchGate+1

  4. Repurposing Rifaximin

    • Authors: [Authors not specified]

    • Year: 2024

    • Details: [Details not available]

🧪 Drug Discovery & Natural Compound Research

  1. Investigating the Chemo-Preventive Role of Noscapine in Lung Carcinoma via Therapeutic Targeting of Human Aurora Kinase B

    • Authors: [Authors not specified]

    • Journal: Molecular and Cellular Biochemistry

    • Year: 2024

    • Citations: 3

    • DOI: 10.1007/s11010-024-05036-7

  2. Probing Baicalin as Potential Inhibitor of Aurora Kinase B: A Step Towards Lung Cancer Therapy

    • Authors: Noor Saba, Arunabh Choudhury, Ali Raza, Anam Ashraf

    • Journal: International Journal of Biological Macromolecules

    • Year: 2024

    • DOI: 10.1016/j.ijbiomac.2023.128813

  3. Natural Compounds vs. Klebsiella

    • Authors: [Authors not specified]

    • Journal: Fitoterapia

    • Year: 2023

    • DOI: [DOI not available]

  4. CDK5 as Neuro Target

    • Authors: [Authors not specified]

    • Journal: International Journal of Biological Macromolecules

    • Year: 2023

    • DOI: [DOI not available]

  5. Triazole Inhibitor for Mycobacterium tuberculosis

    • Authors: [Authors not specified]

    • Journal: Proteins

    • Year: 2022

    • DOI: [DOI not available]

🧫 Tuberculosis & Metabolic Studies

  1. Histidine Biosynthesis in TB

    • Authors: [Authors not specified]

    • Journal: Communications Biology

    • Year: 2021

    • Citations: 10+

    • DOI: [DOI not available]

  2. Lipid Utilization in TB

    • Authors: [Authors not specified]

    • Journal: Journal of Biological Chemistry

    • Year: 2017

    • DOI: [DOI not available]

  3. Bacterioferritin Structure

    • Authors: [Authors not specified]

    • Journal: Acta Crystallographica Section F

    • Year: 2018

    • DOI: [DOI not available]

🫁 Disease-Focused Studies

  1. Molecular Blueprint of COPD

    • Authors: [Authors not specified]

    • Journal: Oxidative Medicine and Cellular Longevity

    • Year: 2023

    • Citations: 6

    • DOI: [DOI not available]

  2. Mineral Pitch and Cancer

    • Authors: [Authors not specified]

    • Journal: BMC Complementary and Alternative Medicine

    • Year: 2016

    • DOI: [DOI not available]

Conclusion

Dr. Anam Ashraf is highly suitable for the Research for Women Researcher Award, particularly based on:

  • Her consistent and impactful contributions to life sciences,

  • Strong publication and presentation record in relevant domains,

  • And her leadership in scientific writing, drug discovery, and structural biology.

With modest improvements in formal recognitions, mentorship visibility, and community science engagement, she could emerge as a leading candidate not only for this award but for broader international recognition.