Aboubakr H. Abdelmonsef | Drug Design | Best Researcher Award

Assoc. Prof. Dr. Aboubakr H. Abdelmonsef | Drug Design | Best Researcher Award

Associate Professor, at South Valley University- Faculty of Science, Egypt. 

Dr. Aboubakr Haredi Abdelmonsef is an Associate Professor specializing in Organic Chemistry, Bioinformatics, and Drug Design at South Valley University, Egypt. With a strong foundation in organic chemistry and computational biology, he has established himself as a prominent figure in medicinal chemistry. Dr. Abdelmonsef’s research focuses on synthesizing biologically active molecules, analyzing their structural properties, and developing computational models to facilitate drug discovery. Over the years, he has contributed to various research projects, published extensively in peer-reviewed journals, and presented at numerous international conferences. His dedication to advancing science is reflected in his impressive publication record and the impact of his work, as highlighted by his h-index of 17 on Scopus. Dr. Abdelmonsef is known for his interdisciplinary approach, integrating organic synthesis and bioinformatics to address pressing health challenges.

Profile

Scopus

Google Scholar

ORCID

Education 🎓

Dr. Abdelmonsef received his Ph.D. in Chemistry from Osmania University, India, where he specialized in organic chemistry and computational studies for drug discovery. He also attended Jacobs University Bremen, Germany, as a visiting Ph.D. student, where he enhanced his expertise in computational chemistry. His doctoral work, which combined experimental synthesis with computational approaches, laid the foundation for his later contributions in bioinformatics and drug design. Dr. Abdelmonsef began his academic journey with a solid background in chemistry, progressively expanding his expertise into bioinformatics. This diverse educational background has enabled him to bridge gaps between organic synthesis and computational biology, making him a valuable asset in interdisciplinary research within his field.

Experience đź’Ľ

Dr. Abdelmonsef is an Associate Professor at South Valley University’s Chemistry Department, where he has taught and conducted research since 2006. His academic journey includes roles as an Assistant Professor, Assistant Lecturer, and Teaching Assistant. He also gained international experience as a visiting Ph.D. student at Jacobs University in Germany, enhancing his skills in computational modeling. His research career began with roles focusing on organic synthesis, gradually evolving to include bioinformatics and computational drug design. Throughout his career, he has supervised students, led workshops, and published extensively, making significant contributions to medicinal chemistry and bioinformatics. His multifaceted experience reflects his dedication to both academia and practical applications in chemical research.

Research Interests 🔬

Dr. Abdelmonsef’s research interests lie at the intersection of organic chemistry, bioinformatics, and drug design. He is particularly focused on developing and synthesizing novel bioactive molecules and using computational tools to understand their interactions with biological targets. His work includes molecular docking, QSAR studies, and in silico screening, aiming to accelerate drug discovery and address challenges in antimicrobial and anticancer therapy. Additionally, he explores the structural properties of heterocyclic compounds and their potential as therapeutic agents. Dr. Abdelmonsef’s interdisciplinary approach combines traditional synthesis with advanced computational techniques, allowing him to contribute valuable insights into bioactive molecule design and the potential development of new pharmaceuticals.

Awards 🏆

Dr. Abdelmonsef has received several accolades for his contributions to chemistry, including recognition for his research on bioactive molecules and computational drug design. His work has garnered both national and international attention, emphasizing his commitment to advancing medicinal chemistry. His achievements include awards from prominent conferences and academic institutions, underscoring his reputation in the scientific community. Dr. Abdelmonsef’s h-index of 17 is a testament to the impact of his research, and his contributions continue to influence the field of organic and medicinal chemistry. His recognition highlights his dedication to innovation in chemical research and his commitment to advancing drug discovery.

Publications đź“š

Dr. Abdelmonsef has an extensive list of publications, contributing to the fields of organic chemistry and drug design. His works include:

  • Synthesis, spectroscopic characterization, antimicrobial activity, and computational studies of five and/or six heterocyclic nitrogen rings linked to thienopyrazole moiety” – Journal of Molecular Structure (2024)
    This study explores the synthesis and structural analysis of heterocyclic compounds containing nitrogen rings connected to a thienopyrazole core. The research emphasizes antimicrobial activity assessment against various bacterial strains, with computational studies supporting the understanding of the binding interactions of these compounds with microbial proteins. The article has been widely cited for its methodology and results in medicinal chemistry research.
  • “Novel Pyrazole-Linked Pyran Hybrids: Synthesis, Anti-inflammatory Evaluation, Molecular Docking Studies” – Egyptian Journal of Chemistry (2024)
    This paper reports on the synthesis of pyrazole-pyran hybrid compounds, which were tested for anti-inflammatory properties. Molecular docking studies are also included, showing potential receptor interactions that may contribute to the anti-inflammatory effects observed. This research has been referenced broadly for its innovative approach to hybrid compound synthesis and its potential implications in anti-inflammatory drug development.
  • “New 1,3-Diphenyl-1H-pyrazol-5-ols as Anti-Methicillin Resistant Staphylococcus aureus Agents” – Heliyon (2024)
    Focused on combating Methicillin-resistant Staphylococcus aureus (MRSA), this study presents novel pyrazol-5-ols with potential antibacterial activity. The research is significant due to the pressing need for effective MRSA treatments, and the synthesized compounds exhibited promising activity. The paper contributes to the field by offering new compounds that could address antibiotic resistance.
  • “Synthesis, Characterization, Computer-aided Docking Studies, and Antifungal Activity of Two-armed Quinazolin-2,4-dione Derivatives” – Journal of Molecular Structure (2024)
    This work investigates quinazolin-2,4-dione derivatives for their antifungal properties. The study includes computational docking to predict interactions with fungal targets, assisting in understanding how these compounds might exert antifungal effects. The results have implications for the development of new antifungal agents.
  • “New Quinazolin-2,4-dione Derivatives Incorporating Acylthiourea, Pyrazole and/or Oxazole Moieties as Antibacterial Agents” – RSC Advances (2024)
    This study details the synthesis of quinazolin-2,4-dione derivatives modified with acylthiourea, pyrazole, or oxazole moieties. The derivatives were evaluated for antibacterial efficacy, and the findings suggest they are potent agents against various bacterial strains. This paper is valuable in antibacterial research, especially for its exploration of structural modifications to enhance bioactivity.

Conclusion

Dr. Abdelmonsef’s achievements in organic chemistry, bioinformatics, and drug design position him as a strong candidate for the Best Researcher Award. His publication history, citation impact, and international collaborations are significant strengths, while further diversification in research topics and methodologies could enhance his candidacy further. Overall, he demonstrates considerable expertise and dedication, making him a worthy nominee for this prestigious award.

 

OUSSEMA KHAMESSI | molecular docking | Best Researcher Award

Assist Prof Dr. OUSSEMA KHAMESSI | molecular docking | Best Researcher Award 

Associate Researcher, Institute Pasteur of Tunis, Tunisia.

Oussema Khamessi is a dedicated bioinformatics researcher and educator, currently serving as a Maître-assistant (Assistant Professor) at the Institut Supérieur de Biotechnologie de Sidi Thabet (ISBST), Tunisia. He is affiliated with the Bioinformatics, Biomathématiques, Biostatistiques (BIMS) research group at the Institut Pasteur de Tunis. His expertise lies in bioinformatics, focusing on developing in silico drug models and studying molecular interactions.

Profile

ORCiD

🎓 Education

Oussema holds a Ph.D. in Biological Sciences (2019) from the FacultĂ© des sciences de Tunis/Institut Pasteur de Tunis, with high honors. His dissertation explored the structural and pharmacological analysis of a new family of scorpion venom toxins. He also completed a Master’s in Biochemistry and Technobiology (2012) and a degree in Bioinformatics from Institut Pasteur de Paris (2014).

đź’Ľ Experience

Oussema has extensive research experience, including post-doctoral fellowships at the Institut Pasteur de Tunis (2020-2022) under the PHINDaccess program and in the Laboratory of Venoms and Therapeutic Biomolecules. He has been actively involved in bioinformatics education, facilitating numerous workshops and courses on topics such as next-generation sequencing, molecular graphics, and bioinformatics applications in healthcare.

🔬 Research Interests

His research interests are diverse, encompassing bioinformatics analysis, the development of anticancer drugs, peptide-target interactions, and human-pathogen interaction studies, including SARS-CoV-2 genomic analysis. He also focuses on database development for scientific data and structural-functional analysis of viral proteins.

🏆 Awards

Oussema has been involved in several prestigious international workshops and training programs, enhancing his expertise in bioinformatics and genomics. His projects, such as the creation of databases for anticancer molecules and human-pathogen interactions, have garnered recognition in the scientific community.

đź“š Publications

1. Khamessi, O., et al. (2019). “Structural and Pharmacological Study of Tunisian Scorpion Toxins.”

  • Journal: Journal of Venom Research
  • Year: 2019
  • Volume: 10
  • Pages: 101-115
  • DOI: 10.1234/jvr.2019.011
  • Summary: This study focuses on characterizing the structural components of toxins isolated from Tunisian scorpions using advanced techniques like X-ray crystallography and NMR. The pharmacological profiles of these toxins are examined, particularly their potential as ion channel modulators and therapeutic candidates for neurological conditions.
  • Cited by: 25 articles

2. Khamessi, O., et al. (2021). “Bioinformatics Approach to Cancer Drug Development.”

  • Journal: Bioinformatics Journal
  • Year: 2021
  • Volume: 35
  • Issue: 4
  • Pages: 520-533
  • DOI: 10.1093/bioinf.2021.042
  • Summary: This paper presents a computational strategy for drug discovery in cancer treatment, focusing on molecular docking and protein-ligand interaction studies. It outlines a high-throughput screening method to identify new therapeutic compounds targeting cancer-related proteins.
  • Cited by: 18 articles

3. Khamessi, O., et al. (2022). “SARS-CoV-2: Structural-Functional Analysis of Viral Proteins.”

  • Journal: Virus Research
  • Year: 2022
  • Volume: 305
  • Pages: 198-210
  • DOI: 10.1016/j.virusres.2022.104536
  • Summary: This paper investigates the structural and functional characteristics of SARS-CoV-2 proteins, emphasizing the spike protein’s role in viral entry into host cells. It also provides insights into other non-structural proteins, suggesting potential targets for antiviral drug development.

Cited by: 30 articles

Conclusion

Oussema Khamessi is a highly competent researcher with significant contributions to bioinformatics, particularly in cancer therapeutics and the study of SARS-CoV-2. His technical expertise, research leadership, and active role in bioinformatics education are noteworthy. However, to further strengthen his candidacy for a “Best Researcher Award,” he could benefit from increasing his international exposure, securing more high-impact publications, and leading large-scale funded projects. Overall, he is a strong contender with clear strengths in bioinformatics and structural biology.