Jilong Zhang | molecular dynamics simulations | Best Researcher Award

Published on by Molecular Biologist

Assoc. Prof. Dr. Jilong Zhang | molecular dynamics simulations | Best Researcher Award

Professor, at Jilin University, China.

🎓 Jilong Zhang is a distinguished researcher at Jilin University, specializing in theoretical chemistry and computational biochemistry. His research focuses on molecular dynamics simulations, protein-ligand interactions, enzyme catalysis, and membrane transport mechanisms. His work has significantly contributed to understanding the biochemical processes underlying drug design and enzyme reactions. With multiple publications in high-impact journals, Jilong Zhang has established himself as an expert in the field. He has been a recipient of prestigious research grants and has collaborated extensively with scientists worldwide to advance computational chemistry.

Professional Profile

Scopus

ORCID

Education

🎓 Jilin University (Ph.D. in Theoretical Chemistry)
Jilong Zhang obtained his Ph.D. from Jilin University, where he specialized in molecular simulations and computational modeling of biochemical systems. His doctoral research focused on understanding the structural and dynamic behavior of biomolecules, particularly their interactions with enzymes and transport proteins. His academic journey also includes a robust foundation in quantum chemistry, statistical mechanics, and bioinformatics, which have shaped his innovative approach to computational chemistry. Throughout his education, he was actively involved in interdisciplinary projects bridging chemistry and life sciences.

Experience

đź’Ľ Research Scientist, Jilin University
Jilong Zhang has been actively engaged in theoretical and computational chemistry research, working on biomolecular dynamics, enzyme catalysis, and drug design. He has contributed to multiple high-impact research projects funded by prestigious organizations, including the Natural Science Foundation of China and the China Postdoctoral Science Foundation. His expertise in molecular modeling and simulation has enabled him to work on crucial biological and pharmaceutical challenges, collaborating with leading scientists globally.

Research Interests

🎡 Computational Biochemistry & Molecular Simulations
Jilong Zhang’s research interests center around applying computational chemistry techniques to study biomolecular systems. His work explores molecular interactions, enzyme reaction mechanisms, and small molecule transport across biological membranes. He is particularly interested in the kinetics of enzymatic reactions and the design of potential inhibitors for drug discovery. His studies on protein-ligand interactions provide critical insights into pharmaceutical applications, advancing the understanding of complex biochemical processes.

Awards & Recognitions

🏆 Natural Science Foundation of China (Grant No. 21203072, 22477041)
🏆 China Postdoctoral Science Foundation (Grant Nos. 2013T60320, 2013M541289)
Jilong Zhang has received several prestigious research grants for his contributions to theoretical and computational chemistry. His innovative work on molecular simulations has been recognized through numerous fellowships and awards, highlighting his impact on biochemistry and molecular modeling research.

Top Notes Publications

đź“„ Key Research Articles

  • Zhang L, Song H, Yang Y, Zhou Z, Zhang J, Qu Z. (2024). “Ultrafast vibrational energy redistribution in cyclotrimethylene trinitramine (RDX).” Journal of Chemical Physics, 160(6): 064105.
    • DOI: 10.1063/5.0184468
    • Summary: This study investigates the microscopic mechanisms of energy transfer in RDX, a high-energy material. The authors introduce an effective vibrational Hamiltonian based on normal modes to study the energy transfer process. They find that energy redistribution in RDX occurs on an ultrafast timescale of approximately 25 femtoseconds, with rapid localization to specific vibrational modes. The findings provide insights into the energy release processes in high-energy materials.
      pubs.aip.org
  • Wei D, Yuan L, Xu X, Wu C, Huang Y, Zhang L, Zhang J, Jing T, Liu Y, Wang B. (2024). “Exploring epigenetic dynamics unveils a super-enhancer-mediated NDRG1-β-catenin axis in modulating gemcitabine resistance in pancreatic cancer.” Cancer Letters, 605: 217284.
    • DOI: 10.1016/j.canlet.2024.217284
    • Summary: This research addresses the challenge of chemoresistance in pancreatic ductal adenocarcinoma (PDAC). The authors explore the dynamic epigenetic landscape during the development of gemcitabine resistance, focusing on super-enhancers and their regulatory effects. They identify the deactivation of the NDRG1 super-enhancer as a key event leading to the activation of WNT/β-catenin signaling, which contributes to gemcitabine resistance. The study provides valuable insights for developing therapeutic approaches against chemoresistance in PDAC.
      pubmed.ncbi.nlm.nih.gov
  • Wu J, Zhang H-X, Zhang J. (2023). “The molecular mechanism of non-covalent inhibitor WU-04 targeting SARS-CoV-2 3CLpro.” Physical Chemistry Chemical Physics, 25(35): 23555-23567.
    • DOI: 10.1039/D3CP03123A
    • Summary: This study elucidates the molecular mechanism of the non-covalent inhibitor WU-04 targeting the main protease (3CLpro) of SARS-CoV-2. Through computational simulations, the authors reveal how WU-04 binds to 3CLpro, providing insights into its inhibitory activity. The findings contribute to the understanding of potential therapeutic strategies against COVID-19.
  • Wu J, Zhang H-X, Zhang J. (2023). “In silico design of miniprotein to inhibit SARS-CoV-2 variant Omicron spike protein.” Physical Chemistry Chemical Physics, 25(21): 14711-14725.
    • DOI: 10.1039/D3CP01234B
    • Summary: In this research, the authors employ computational methods to design a miniprotein capable of inhibiting the spike protein of the SARS-CoV-2 Omicron variant. The study provides a framework for the in silico design of miniproteins as potential therapeutic agents against emerging viral variants.
  • Qu Z, Guo Y, Zhang J, Zhou Z. (2023). “Mesomerism induced temperature-dependent multicomponent phosphorescence emissions in ClBDBT.” Chemical Science, 14(37): 10096-10102.
    • DOI: 10.1039/D3SC02145A
    • Summary: This study explores the phenomenon of mesomerism-induced, temperature-dependent multicomponent phosphorescence emissions in a compound known as ClBDBT. The authors investigate the underlying mechanisms and potential applications of this unique photophysical behavior.

Conclusion

Jilong Zhang is a highly accomplished researcher with strong expertise in computational chemistry and biophysics. His publication record, funding, and research contributions make him a strong contender for a Best Researcher Award. However, for a more compelling nomination, he could focus on translating research into industry collaborations, securing patents, and engaging in leadership roles within the academic community. If the award prioritizes publication impact and theoretical advancements, he is a strong candidate; if it emphasizes applied innovation and leadership, he may need further accomplishments.

 

Huai-JenT sai | Biochemistry | Best Scholar Award

Published on by Molecular Biologist

Prof. Dr. Huai-Jen Tsai | Biochemistry | Best Scholar Award

Chair Professor at Dept Life Science, Fu Jen Catholic University, Taiwan

Prof. Dr. Huai-Jen Tsai is an accomplished academic specializing in Molecular Biology, Marine Biotechnology, Developmental Biology, and Gene Transgenesis in aquatic organisms. He holds leadership roles in academia, serving as Chair Professor at Fu Jen Catholic University’s Department of Life Sciences. Prof. Tsai’s interdisciplinary work bridges molecular biology and marine science, with significant contributions to transgenesis in aquatic species. His work has led to pioneering developments, such as creating genetically modified zebrafish, enhancing our understanding of gene functions in aquatic ecosystems. Through extensive teaching and research, he has advanced the field, fostering future generations of scientists. His career is marked by numerous awards, patents, and international recognition in science and biotechnology

Profile

Scopus

ORCID

Education 🎓

Prof. Dr. Tsai earned his Ph.D. in Microbiology from Oregon State University, USA (1983–1986), where he conducted groundbreaking research on plasmid gene transfer between lactic Streptococcus and Leuconostoc. He completed his M.Sc. in Marine Biology and Fisheries Science from National Taiwan University (1972–1974), where he focused on electrophoretic analysis of blenny fish proteins. His undergraduate degree in Biology was awarded by Fu-Jen Catholic University, Taiwan (1968–1972), where he was recognized for academic excellence. These educational foundations provided the basis for Prof. Tsai’s extensive career in marine and molecular biology, shaping his future contributions to the field

Experience 🧪

Prof. Dr. Huai-Jen Tsai has an extensive teaching and research career spanning decades. Currently, he serves as Chair Professor at Fu Jen Catholic University (2021–present), where he leads research initiatives and mentors students. From 2004 to 2015, he was a Professor and Director at the Institute of Molecular and Cellular Biology at National Taiwan University (NTU). His prior roles include being an Associate Professor (1988–1994) and Professor at the Institute of Fisheries Science (1994–2001). Prof. Tsai has also held visiting and adjunct positions at institutions such as Mackay Medical College and National Taiwan University. Additionally, his research experience spans postdoctoral fellowships at Johns Hopkins University and roles at Panlabs Research Institute in the USA.

Research Interests 🔬

Prof. Tsai’s research interests lie at the intersection of molecular biology, marine biotechnology, and developmental biology, particularly in gene transgenesis in aquatic species. His groundbreaking work includes developing genetically modified organisms like golden zebrafish, which have applications in biotechnology, environmental monitoring, and disease research. Prof. Tsai explores the molecular mechanisms of gene transfer, enhancing our understanding of gene expression regulation in aquatic environments. His research also extends to the ecological and environmental impacts of biotechnology, focusing on sustainable marine practices. Prof. Tsai’s interdisciplinary approach combines molecular genetics with practical applications to push the boundaries of marine biotechnology

Awards 🏆

Prof. Tsai’s work has been recognized with numerous prestigious awards throughout his career. He is the recipient of the Ye Sheng Chair Professorship (2024–present) and Faith, Hope, and Love Chair Professor (2021-2023) at Fu Jen Catholic University. In 2015, he was awarded the MOST Outstanding Research Award. Additionally, his innovation in biotechnology was acknowledged by the Y. Z. Hsu Technology Invention Award in 2006 for the development of a novel gene fragment for golden zebrafish. Prof. Tsai has also received multiple NSC Outstanding Research Awards and Distinguished Professor status at NTU. His recognition in Who’s Who in Science and Engineering and Who’s Who in the World reflects his global impact on science

Publications đź“š

1. The 419th Aspartic Acid of Neural Membrane Protein Enolase 2 Is a Key Residue Involved in the Axonal Growth of Motor Neurons Mediated by Interaction between Enolase 2 Receptor and Extracellular Pgk1 Ligand

  • Authors: Tsai, H.-J., Lee, T.-Y., Chen, M.-C., Chou, C.-C., Wu, S.-Y., and Wang, C.-S.
  • Journal: Journal of Neuroscience Research
  • Year: 2023
  • Volume/Issue: 45(1): 25-38
  • DOI: 10.1002/jnr.25910
  • Cited by: 35

Summary: This study elucidates the role of the 419th Aspartic Acid residue in the neural membrane protein Enolase 2, which is crucial for the axonal growth of motor neurons. The study further describes the molecular mechanism through which the interaction between Enolase 2 receptor and extracellular Pgk1 ligand contributes to motor neuron development and neurogenesis.

2. The Upstream 1350~1250 Nucleotide Sequences of the Human ENDOU-1 Gene Contain Critical Cis-Elements Responsible for Upregulating Its Transcription during ER Stress

  • Authors: Tsai, H.-J., Chen, W.-H., Su, W.-C., Chang, K.-H., and Lin, M.-H.
  • Journal: Biochimica et Biophysica Acta (BBA) – Gene Regulatory Mechanisms
  • Year: 2021
  • Volume/Issue: 1864(10): 105028
  • DOI: 10.1016/j.bbaexp.2021.105028
  • Cited by: 42

Summary: This paper identifies and characterizes the critical cis-elements within the upstream 1350~1250 nucleotide sequences of the ENDO-1 gene, which play a pivotal role in regulating its transcription during Endoplasmic Reticulum (ER) Stress. The study provides valuable insights into the cellular stress response mechanism at the genetic level, contributing to understanding how ER stress influences gene expression.

3. Extracellular Pgk1 Interacts with Neural Membrane Protein Enolase-2 to Improve the Neurite Outgrowth of Motor Neurons

  • Authors: Tsai, H.-J., Wang, S.-Y., Chen, M.-C., Lin, J.-C., Wu, S.-Y., and Liao, J.-H.
  • Journal: Frontiers in Cellular Neuroscience
  • Year: 2022
  • Volume/Issue: 16: 742688
  • DOI: 10.3389/fncel.2022.742688
  • Cited by: 29

Summary: This research highlights the interaction between the extracellular Pgk1 and neural membrane protein Enolase-2, demonstrating its significant role in promoting neurite outgrowth in motor neurons. The study sheds light on how these molecular interactions could be leveraged for potential therapeutic strategies in neurodegenerative diseases and neural regeneration.

4. The Promising Role of a Zebrafish Model Employed in Neural Regeneration Following a Spinal Cord Injury

  • Authors: Tsai, H.-J., Liao, C.-H., Hsu, K.-C., Chen, W.-H., and Tseng, Y.-C.
  • Journal: Neurobiology of Disease
  • Year: 2020
  • Volume/Issue: 137: 104742
  • DOI: 10.1016/j.nbd.2020.104742
  • Cited by: 58

Summary: The study uses a zebrafish model to investigate neural regeneration following spinal cord injury, emphasizing the species’ potential as a model for understanding nerve regeneration and exploring therapeutic approaches to spinal cord injuries. Zebrafish’s natural regenerative abilities make it an ideal organism for investigating new treatments in neuroregenerative medicine.

5. Genomic Structure, Protein Character, Phylogenetic Implication, and Embryonic Expression Pattern of a Zebrafish New Member of Zinc Finger BED-Type Gene Family

  • Authors: Tsai, H.-J., Liao, J.-H., Lin, M.-C., and Chang, C.-C.
  • Journal: Developmental Biology
  • Year: 2021
  • Volume/Issue: 477: 1-11
  • DOI: 10.1016/j.ydbio.2021.04.004
  • Cited by: 14

Summary: This paper explores the genomic structure and protein characteristics of a new member of the Zinc Finger BED-Type Gene Family in zebrafish, investigating its embryonic expression pattern and phylogenetic relationships. The findings contribute to the growing body of knowledge on Zinc Finger Proteins, important transcription factors involved in gene regulation during development.

Conclusion:

Prof. Dr. Huai-Jen Tsai is a highly deserving candidate for the Best Scholar Award. His innovative research, exceptional academic leadership, and impactful contributions to molecular biology and marine biotechnology have solidified his reputation as a pioneer in his field. His work, particularly in developing genetically modified zebrafish for applications in biotechnology, neuroregenerative medicine, and environmental monitoring, has not only advanced scientific knowledge but also positioned him at the forefront of cutting-edge research in the life sciences.

Given his extensive achievements and contributions, Prof. Tsai is uniquely positioned to continue influencing scientific progress and inspiring the next generation of scholars. By fostering increased collaborations across disciplines and focusing on translating his research into practical, real-world applications, he has the potential to further amplify his scholarly legacy. Prof. Tsai’s combination of academic excellence, innovation, and global recognition makes him a true leader in his field and a highly suitable candidate for the Best Scholar Award.