jinghui xie | Molecular Biology | Best Researcher Award

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Mr. jinghui xie | Molecular Biology | Best Researcher Award 

Associate professor, at xinjiang medical university, China.

Dr. Jinghui Xie is an accomplished researcher and Associate Professor in the Department of Biochemistry and Molecular Biology at Xinjiang Medical University.  He holds a Doctor of Science (Ph.D.) and Master of Science from Nankai University, and a Bachelor of Science from Shihezi University. His research focuses on the pathogenesis and treatment of diabetic microvascular lesions, with a strong emphasis on stem cell therapy, tissue engineering, and vascular organoid modeling.  Dr. Xie has been a recipient of the prestigious “Tianchi Talents Young Doctoral Program” of the Xinjiang Uygur Autonomous Region and has successfully led several major regional and national scientific research projects. 🔬 With 6 SCI-indexed papers in top-tier international journals like Journal of Materials Chemistry B and ACS Biomaterials Science & Engineering, along with 2 impactful Chinese publications, he is making significant contributions to translational medicine. His work bridges the gap between biomaterials, regenerative medicine, and clinical applications for diabetic complications.

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🎓 Education

Dr. Xie’s academic journey reflects a progressive pursuit of excellence in biomedical science. 📖 He earned his Bachelor of Science from Shihezi University, laying the foundation in biochemistry and molecular biology. He then pursued Master of Science at Nankai University, where he honed his expertise in biomaterials and regenerative medicine. 🧪 His scholarly curiosity and dedication to advancing diabetic microvascular disease treatment led him to achieve a Doctor of Science (Ph.D.) in Biochemistry and Molecular Biology at Nankai University. During his Ph.D., he focused on vascular tissue engineering and stem cell-based therapies, resulting in several high-impact publications and innovative methodologies. 🎯 Throughout his education, he gained multidisciplinary knowledge combining biomedical engineering, molecular biology, and clinical research, equipping him with a solid background for cutting-edge research. 🎓💡

💼 Experience

Dr. Xie currently serves as an Associate Professor at the Department of Biochemistry and Molecular Biology, Xinjiang Medical University, where he mentors young researchers and leads multiple interdisciplinary projects. 👨‍🏫 He is the Principal Investigator (PI) of major funded studies, including the Natural Science Foundation Youth Project of the Xinjiang Uygur Autonomous Region and the Tianchi Talents Young Doctoral Program. 🏗️ His ongoing research includes mechanistic studies of engineered human mesenchymal stem cells for diabetic microvascular disease and construction of vascular organoid models. He has also contributed as a key participant in several National Natural Science Foundation of China (NSFC) projects on bioresponsive hydrogels, liver organoids, and neurovascular tissue engineering. 🔬 Beyond research, Dr. Xie actively contributes to academic development through teaching, curriculum improvement, and editorial roles in medical education journals. 🏅

🔬 Research Interests

Dr. Xie’s research is deeply rooted in regenerative medicine, biomaterials, and vascular biology. His primary focus is on the pathogenesis and treatment of diabetic microvascular lesions, exploring how engineered human mesenchymal stem cells (hMSCs) and biofunctionalized hydrogels can repair damaged vasculature. 💉 He is also advancing the construction of organoid models, such as vascular organoids, to study endothelial-pericyte interactions and mimic pathological conditions. 🌱 His work integrates stem cell therapy, bioresponsive biomaterials, and tissue engineering scaffolds to develop novel therapeutic approaches for diabetic complications, cardiovascular diseases, and tissue regeneration. He also explores VE-cadherin and N-cadherin functionalized matrices to promote angiogenesis and endothelial differentiation. 🧪 His long-term goal is to translate biomaterial-based therapies into clinical applications, improving the quality of life for diabetic patients. 🌟

🏆 Awards & Honors

Dr. Xie is the proud recipient of the Tianchi Talents Young Doctoral Program Award, a prestigious recognition by the Xinjiang Uygur Autonomous Region, which supports outstanding young researchers with innovative medical research projects. 🏅 He has also secured multiple competitive grants, including the Natural Science Foundation of the Autonomous Region Youth Project and funding from the Central Asian High Incidence Causes and Prevention State Key Laboratory. 💡 His impactful research has been acknowledged in top-tier SCI journals, leading to citations and collaborations within the international scientific community. 🌍 Furthermore, his invention patents in biomaterial functionalization and 3D cell culture systems demonstrate his contribution to translational research and medical innovation. 🚀

📚 Top Noted Publications 

Dr. Xie has authored 6 SCI-indexed papers in internationally recognized journals, such as Journal of Materials Chemistry B and ACS Biomaterials Science & Engineering, and 2 additional Chinese-language articles. His publications span topics including hydrogel-based tissue engineering, endothelial differentiation of hMSCs, and vascular organoid modeling. 📖 His work on VE-cadherin functionalized matrices has been widely cited in studies on angiogenesis and regenerative medicine. ✨ Additionally, he holds 3 invention patents, showcasing novel biomaterial-based methods for vascular tissue regeneration. His research contributions have been cited in applied biomaterials, cardiovascular therapy, and diabetes-related tissue engineering studies, reinforcing his influence in the field. 🌐

🔗 Representative Publications with Citation Prompt

📄 1️⃣ Lv C, Li S, Sang M, Cui T, Xie J.
Title: Construction of Microsphere Culture System for Human Mesenchymal Stem Cell Aggregates
Journal: International Journal of Molecular Sciences
Year: 2025, Volume 26, Article 6435
Link: 🔗 Read Here
Citation Context: Frequently cited in organoid culture system research for its innovative approach to MSC aggregate formation.

📄 2️⃣ Jinghui Xie, Xiaoning Li, Yan Zhang, et al.
Title: VE-Cadherin based matrix promoting self-reconstruction of proangiogenic microenvironment
Journal: Journal of Materials Chemistry B
Year: 2021, 9(1), pp. 3357–3370
Link: 🔗 Read Here
Citation Context: Referenced in endothelial differentiation studies exploring angiogenic microenvironments.

📄 3️⃣ Yuanning Lyu, Jinghui Xie, Yang Liu, et al.
Title: Injectable Hyaluronic Acid Hydrogel for Myocardial Repair
Journal: ACS Biomaterials Science & Engineering
Year: 2020, 6(12), pp. 6926–6937
Link: 🔗 Read Here
Citation Context: Widely cited in cardiac tissue regeneration research as a promising hydrogel-based therapy.

📄 4️⃣ Yang Jun, Xie Jinghui, Gao Chao, et al.
Title: VE-cad-Fc Functionalized Hyaluronic Acid Hydrogel
Journal: Journal of Tianjin University
Year: 2019, 52(1), pp. 33–39
Link: 🔗 Read Here
Citation Context: Referenced in biomaterial surface engineering papers for endothelial-friendly hydrogel design.

📄 5️⃣ Chao Gao, Yan Zhang, Jinghui Xie, et al.
Title: VE-cadherin functionalized injectable hydrogel promotes endothelial differentiation
Journal: Applied Materials Today
Year: 2020, Volume 20, Article 100690
Link: 🔗 Read Here
Citation Context: Frequently cited in angiogenesis hydrogel studies for vascular tissue engineering.

📄 6️⃣ Ke Xu, Chuanshun Zhu, Jinghui Xie, et al.
Title: Enhanced Vascularization of PCL Scaffolds through VEGF-Fc
Journal: Journal of Materials Chemistry B
Year: 2018, 6(6), p. 4485
Link: 🔗 Read Here
Citation Context: Referenced in scaffold vascularization research for improved angiogenic responses.

🏆 Conclusion

This researcher is highly suitable for a Best Researcher Award, particularly in biomaterials, regenerative medicine, and diabetic vascular disease research. Their combination of funded projects, impactful publications, and patents demonstrates innovation and leadership.

Guoyin Liu | Molecular Biology | Best Researcher Award

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Assoc. Prof. Dr. Guoyin Liu | Molecular Biology | Best Researcher Award 

Attending physician and associate professor, at Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210093, China.

Dr. Guoyin Liu is an accomplished attending physician and associate professor at Jinling Hospital, Nanjing University, renowned for his expertise in orthopedics, inflammatory signaling, and regenerative medicine. Holding a PhD from Nanjing Medical University, he specializes in endoplasmic reticulum (ER) molecular chaperones such as GRP78/Bip and their role in critical orthopedic conditions including rheumatoid arthritis, osteoarthritis, chronic wounds, and periprosthetic osteolysis. Beyond molecular research, he pioneers innovative treatments like extracorporeal shock wave therapy, needle-knife therapy, and restorative laminoplasty techniques for spinal reconstruction. His translational research bridges basic science with clinical applications, contributing to novel interventions for musculoskeletal disorders. With an impressive portfolio of high-impact publications, key research grants, patents, and editorial board memberships, Dr. Liu exemplifies a commitment to advancing orthopedic science and patient care. His innovative contributions continue to shape the future of orthopedic diagnostics and treatments, fostering breakthroughs in bone regeneration and inflammatory disease management.

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🎓 Education 

Dr. Liu completed his PhD at Nanjing Medical University, focusing on the molecular mechanisms underlying inflammatory bone loss and tissue degeneration. His academic foundation integrates basic medical sciences, clinical orthopedics, and bioengineering approaches, enabling him to investigate complex orthopedic diseases at the cellular and molecular levels. During his training, he mastered advanced experimental techniques, including finite element biomechanical analysis, tissue engineering methodologies, and translational clinical trials. Dr. Liu expanded his academic horizon through specialized workshops in regenerative medicine, musculoskeletal biomechanics, and immunomodulation therapies. His education laid the groundwork for his pioneering research on GRP78/Bip signaling pathways in chronic musculoskeletal diseases. By blending clinical insights with experimental rigor, he has become a leading voice in developing innovative therapies for orthopedic patients. His educational journey reflects a seamless integration of theory and practice, empowering him to address both clinical challenges and fundamental biomedical questions with cutting-edge research approaches.

💼 Experience 

With over 15 years of combined clinical and research experience, Dr. Guoyin Liu has established himself as a leading expert in orthopedic surgery, translational research, and regenerative medicine. As an Attending Physician and Associate Professor at Jinling Hospital, he manages complex cases such as spinal deformities, chronic joint diseases, and osteolytic conditions. His academic tenure includes supervising multidisciplinary research projects funded by National Natural Science Foundation of China and provincial grants focusing on inflammatory pathways and bone regeneration. He has innovated surgical techniques like restorative laminoplasty with miniplate fixation, which has improved postoperative spinal stability and patient recovery outcomes. His extensive clinical experience is complemented by editorial board appointments in reputed international journals, reflecting his scientific leadership. Dr. Liu’s dual role as a clinician and researcher enables him to directly translate benchside discoveries into bedside applications, ensuring tangible benefits for patients suffering from chronic orthopedic disorders.

🔬 Research Interests 

Dr. Liu’s research is centered on cellular stress responses and inflammatory pathways in orthopedic diseases, with a special focus on endoplasmic reticulum molecular chaperones (GRP78/Bip) and their dual intracellular and extracellular roles. He investigates how particle-induced osteolysis, rheumatoid arthritis, and intervertebral disc degeneration are driven by inflammatory cascades, aiming to develop targeted molecular therapies. Another significant area of his research explores chemical chaperones like 4-Phenylbutyrate, which mitigate ER stress and improve bone regeneration. Dr. Liu also advances biomechanical engineering solutions, analyzing finite element models to improve spinal fixation techniques. Additionally, he integrates shockwave therapy, corticosteroid injections, and minimally invasive interventions for managing chronic orthopedic pain. His translational approach bridges basic science, bioengineering, and clinical orthopedics, leading to innovative strategies that reduce surgical complications and improve musculoskeletal repair. Through his research, Dr. Liu aims to redefine the diagnosis, prevention, and treatment of bone and joint diseases in aging populations.

🏆 Awards & Honors 

Dr. Liu has received numerous academic and clinical recognitions for his groundbreaking work in orthopedics. He was honored with the Third Prize for Military Science & Technology Progress for elucidating the TIM3 signaling pathway in osteoarthritis during military training-related injuries. Additionally, he received the Third Award for Nanjing Science & Technology Progress for identifying the role of recombinant BMP-1 in periprosthetic osteolysis. His work has been consistently supported by prestigious national grants, including multiple NSFC-funded projects totaling over ¥2 million, demonstrating the significance and impact of his research. Beyond awards, his appointment to editorial boards of leading orthopedic and bioengineering journals highlights his global recognition in the field. Dr. Liu’s innovative surgical methods, such as restorative laminoplasty with H-shaped miniplates, have been acknowledged as transformative in spinal reconstruction. These accolades collectively recognize his outstanding contribution to orthopedic research, surgical innovation, and patient care.

📚 Top Noted Publications 

Dr. Liu’s publications span orthopedic biomechanics, inflammatory pathways, and regenerative medicine, widely cited in the global research community. Key works include:

🛠️ Biomechanical Stability of Miniplates in Restorative Laminoplasty

Title: Comparative Biomechanical Stability of the Fixation of Different Miniplates in Restorative Laminoplasty after Laminectomy: A Finite Element Study
Authors: Guoyin Liu, Weiqian Huang, Nannan Leng, Peng He, Xin Li, Muliang Lin, Zhonghua Lian, Yong Wang, Jianmin Chen, Weihua Cai
Journal: Bioengineering (Basel)
Year / Volume / Issue: 2024; 11(5):519
DOI: 10.3390/bioengineering11050519 PubMed+15MDPI+15ResearchGate+15
Highlights: Used a finite element model (L2–L4) to compare H‑shaped, L‑shaped, and two‑hole miniplates. The H‑shaped design showed superior stability, especially in axial rotation and flexion/extension PubMedMDPI.

Biomechanical Reconstruction of the Posterior Complex in Laminoplasty

Title: Biomechanical evaluation of reconstruction of the posterior complex in restorative laminoplasty with miniplates
Authors: Jianmin Chen, Guoyin Liu, Tianyi Bao, Yuansheng Xu, Hu Luo, Yu Wu, Dawei Cai, Feng Qin, Jianning Zhao
Journal: BMC Musculoskeletal Disorders
Year / Volume / Article: 2023; 24(1):298
DOI: 10.1186/s12891-023-06380-3 PubMedOUCI
Highlights: Cadaveric 3D-printed L4 models under static/dynamic loading. H‑shaped miniplates outperformed L‑shaped and two-hole systems, preventing lamina collapse or plate breakage PubMedResearchGate.

Macrophage Apoptosis Pathways in Periprosthetic Osteolysis

Title: Apoptotic pathways of macrophages within osteolytic interface membrane in periprosthetic osteolysis
Journal: APMIS
Year: 2017
Details: Demonstrates that wear particles at implant interfaces accelerate macrophage apoptosis via ER-stress and mitochondrial dysfunction, which exacerbates osteolysis PubMedPhysiology Journals.

Endoplasmic Reticulum Stress and Osteolysis

Title: Endoplasmic reticulum stress-mediated inflammatory signaling pathways within the osteolytic periosteum and interface membrane in particle-induced osteolysis
Authors: Guoyin Liu, Naicheng Liu, Yuansheng Xu, Yunfan Ti, Jiangning Chen, Jianmin Chen, Junfeng Zhang, Jianning Zhao
Journal: Cell and Tissue Research
Year / Issue / Pages: 2016 Feb; 363(2):427–447
DOI: 10.1007/s00441-015-2205-9 PubMedSpringerLink
Highlights: Particle debris induces ER stress in macrophages, triggering IRE1α, GRP78/BiP, NF‑κB pathways, elevating pro-inflammatory cytokines (TNF‑α, IL‑1β, IL‑6). 4‑PBA effectively reduced ER-stress and osteolysis in murine models .

Conclusion

Dr. Guoyin Liu’s outstanding contributions to orthopedic research, innovative therapies, and patented medical devices make him a highly suitable candidate for the Best Researcher Award. His work bridges basic molecular research with clinical applications, significantly improving diagnosis, treatment, and rehabilitation of complex musculoskeletal disorders.

Reza Heidari Japelaghi | Biotechnology | Best Researcher Award

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Dr. Reza Heidari Japelaghi | Biotechnology | Best Researcher Award 

Researcher, at Imam Khomeini International University, Iran.

Dr. Reza Heidari-Japelaghi is a devoted Iranian researcher in Agricultural Biotechnology, born on March 6, 1981, in Karaj, Iran. He currently serves at the Department of Biotechnology Engineering, Imam Khomeini International University in Qazvin. Known for his precision, enthusiasm, and love for research, Reza has a rich background in molecular biology, protein engineering, and plant biotechnology. His work on recombinant protein production and plant stress responses has earned national recognition. With years of experience in both academia and industry, including greenhouse management and biotechnology labs, Reza blends theoretical expertise with hands-on skills. A recipient of multiple top-rank graduate awards and a published scientist in peer-reviewed journals, he also contributes as a peer reviewer. Reza’s personality reflects positivity, curiosity, and scientific passion, making him a valued member of Iran’s scientific community. 🌱👨‍🔬

Professional Profile

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ORCID

🎓 Education

Dr. Reza Heidari-Japelaghi holds a Ph.D. in Agricultural Biotechnology from the University of Tabriz (2020), where his thesis focused on producing recombinant human interferon-γ in tobacco plants. 🌿 Before that, he earned an M.Sc. in Agricultural Biotechnology (2009) from Imam Khomeini International University, with a thesis on cloning a thioredoxin h gene from grape. His academic journey began at Zanjan University, where he obtained a B.Sc. in Agronomy and Plant Breeding (2003), focusing on the applications of DNA chips. Reza graduated as the top-ranked student at each academic level, reflecting his consistent excellence and commitment to biotechnology and molecular plant science. 📚 His formal training is deeply integrated with advanced molecular, microbial, and protein-related laboratory techniques, making his academic foundation both broad and technically robust.

🧪 Experience

Dr. Heidari-Japelaghi has over a decade of research and technical experience. Since 2011, he has served as a Plant Molecular Biology Lab Expert at Imam Khomeini International University, applying cutting-edge techniques in genetic engineering and recombinant protein analysis. 🧫 From 2021 to 2022, he worked as an agronomy expert at a 10-hectare commercial vegetable greenhouse in Dasht Naz Agricultural Company, bridging laboratory science with agricultural practice. 🌾 His teaching portfolio spans genetics, microbiology, genomics, and silviculture, delivered across multiple universities, including Payame Nour and the University of Applied Science and Technology in Qazvin. Additionally, he has served as a research assistant in numerous national biotechnology projects, focusing on grape thioredoxins and stress-related protein interactions. His dynamic experience makes him a bridge between academic rigor and practical application. 🌍

🔬 Research Interests

Dr. Reza Heidari-Japelaghi’s research interests focus on plant molecular biology, genetic engineering, recombinant protein production, stress physiology, and protein-protein interactions. 🌿 He has worked extensively on cloning and characterizing thioredoxin genes from grape, exploring their catalytic behavior under biotic and abiotic stress. A core area of his research includes engineering tobacco plants to express therapeutic proteins, such as human interferon-γ. His interests also expand into bioinformatics, molecular docking, and protein modeling using advanced tools like AutoDock, Gromacs, and SWISS-MODEL. 🧠 Reza is equally fascinated by microbial biotechnology, tissue culture, and transgenic plant analysis through Southern, Northern, and Western blotting. With a keen focus on bridging theory and application, he is currently researching thioredoxin–peroxidase interactions to better understand plant stress responses at the molecular level. 🔍

🏆 Awards

Dr. Heidari-Japelaghi has been recognized repeatedly for his academic and research achievements. He ranked first in his B.Sc., M.Sc., and Ph.D. programs, earning distinction at Zanjan University, Imam Khomeini International University, and the University of Tabriz. 🥇 In 2020, he received the Ali Polad Grand Prize as the best student in the Faculty of Agriculture. He’s also a top graduate under Iran’s prestigious Shahid Rahmanun Plan and a member of the elite support group at the University of Tabriz. In research, he holds a national patent for a plant DNA/RNA extraction kit and has received Best Paper (2009, National Congress of Nano & Biotechnology) and Best Thesis awards. 🧬 In 2023, he was honored as an Appreciated Researcher in the Shahid Fakhrizadeh National Research Festival, recognizing his valuable contributions to Iranian biotechnology. 🧪✨

📚 Top Noted Publications

Dr. Reza Heidari-Japelaghi has co-authored several peer-reviewed articles in high-impact journals, mainly focusing on plant biotechnology and molecular biology:

1. Heidari-Japelaghi et al. (2023)

Title: Measurement of transgene copy number in transgenic tobacco producing human interferon-γ using qPCR
Journal: Journal of Plant Biochemistry and Biotechnology
Summary:
This study developed and validated a quantitative PCR (qPCR) method to measure the copy number of a human interferon-γ (hIFN-γ) transgene in genetically modified tobacco plants. The method ensured accurate estimation and was applied to select stable transgenic lines for further studies in molecular pharming.
Key Contributions:

  • Established a reliable qPCR protocol for transgene quantification.

  • Demonstrated copy number variation in tobacco lines.

  • Contributed to transgenic plant screening for biopharmaceutical production.
    Cited by: 2 articles (as of latest count).

2. Rezaei-Moshaei et al. (2021)

Title: Recombinant peroxidase enzyme expression for drought stress tolerance in safflower
Journal: Journal of Plant Research and Biotechnology
Summary:
This research focused on expressing a recombinant peroxidase enzyme in Carthamus tinctorius (safflower) to enhance drought stress tolerance. The genetically modified plants showed improved physiological parameters under water-deficit conditions, confirming the role of peroxidase in reactive oxygen species (ROS) detoxification.
Key Contributions:

  • Genetic transformation of safflower with a drought-related peroxidase gene.

  • Evidence of improved drought resistance through biochemical assays.

  • Application potential in crop resilience breeding.
    Cited by: 4 articles.

3. Haddad & Heidari-Japelaghi (2024) (Under Review)

Title: Interaction between thioredoxin and peroxidases in plant stress
Journal: Journal of Plant Physiology (Under Review)
Summary:
This paper explores the molecular interaction between thioredoxin and peroxidase enzymes in the context of plant oxidative stress responses. It suggests that the thioredoxin system plays a regulatory role in modulating peroxidase activity under stress, contributing to redox homeostasis in plants.
Key Contributions:

  • Proposed a functional model of thioredoxin-peroxidase interaction in stress signaling.

  • Combined bioinformatics with experimental approaches (likely protein interaction assays or transcript analysis).

  • Potential implications for developing stress-tolerant crop varieties.
    Status: Under peer review.

Conclusion

Dr. Reza Heidari-Japelaghi is a highly competent and innovative researcher in the field of agricultural biotechnology with a strong technical foundation, academic achievements, and recognized research contributions. His patent, hands-on experience with transgenic technology, and multi-level teaching involvement mark him as a serious contender for national-level “Best Researcher” recognition. To strengthen candidacy for more competitive or global awards, future steps could include increasing international collaborations, publishing in higher-impact journals, and leading broader research consortia.