Professor, at Institute of Microbiology, Chinese Academy of Sciences, China.
Dr. Kaixia Mi is a renowned principal investigator at the Institute of Microbiology, Chinese Academy of Sciences, and Medical School, University of Chinese Academy of Sciences. 🏛️ She is a leading expert in tuberculosis (TB) molecular pathogenesis, with a strong focus on latent infection mechanisms and antibiotic resistance in Mycobacterium tuberculosis (Mtb). 🧪 Dr. Mi’s research harnesses cutting-edge techniques such as genomics, proteomics, X-ray crystallography, and cryo-electron microscopy to decipher the survival strategies of TB bacteria under stress conditions. Her team’s work is critical to identifying novel therapeutic targets, offering hope for more effective TB treatments. 🌍 With a steadfast commitment to global health and a multidisciplinary approach, Dr. Mi has made impactful contributions to infectious disease biology and translational research. Her collaborative and pioneering spirit has earned her recognition both in China and internationally. 🥼
Professional Profile
Scopus
🎓 Education
Dr. Kaixia Mi completed her Ph.D. in Microbiology at a prestigious Chinese institution, where she developed a strong foundation in bacterial pathogenesis and host-microbe interaction. 📚 Her postdoctoral training further enhanced her expertise in molecular biology and structural bioinformatics, giving her the interdisciplinary skill set necessary for cutting-edge research in tuberculosis biology. 🔬 She has undertaken specialized training in advanced microscopy and structural biology at world-class laboratories, positioning her to investigate the atomic structure of TB-related proteins. Throughout her academic journey, Dr. Mi has received multiple fellowships and grants for her academic excellence. She has also attended international courses and symposia to enrich her understanding of infectious diseases and resistance mechanisms. 🌐 Her educational background, deeply rooted in both fundamental microbiology and high-resolution structural techniques, has been instrumental in shaping her as a thought leader in TB research. 🧠
🧪 Experience
Dr. Mi currently serves as a Principal Investigator at the Institute of Microbiology, Chinese Academy of Sciences. 🏢 She leads a dynamic research group focused on tuberculosis latency and resistance mechanisms, with dual affiliations at the Medical School, University of Chinese Academy of Sciences. Her team integrates systems biology, chemical biology, and structural elucidation to study Mycobacterium tuberculosis. 🧬 Under her leadership, the lab has made significant advances in understanding TB persistence under stress conditions and during antibiotic exposure. 🧫 Prior to her current role, Dr. Mi gained substantial experience as a postdoctoral researcher in renowned laboratories specializing in bacterial stress responses and high-throughput screening platforms. Over the years, she has mentored numerous graduate students and postdocs, fostering the next generation of infectious disease researchers. 🧑🔬 Her deep understanding of pathogen biology, paired with leadership and collaborative acumen, has led to substantial contributions in translational microbiology. 🌍
🔍 Research Interest
Dr. Kaixia Mi’s research focuses on deciphering the molecular mechanisms underlying latent tuberculosis infection and antimicrobial resistance. 🧪 She aims to understand how Mycobacterium tuberculosis persists within the host during dormant stages and evades current therapies. 🧬 By integrating omics technologies (genomics, transcriptomics, proteomics) with structural biology tools, her team investigates the regulation of stress response genes, persistence-associated proteins, and antibiotic target molecules. 🧫 Dr. Mi also explores host-pathogen interactions, particularly how the bacterium manipulates immune signaling and metabolism to remain undetected. Her research has major implications in identifying novel drug targets, especially those effective against dormant or drug-resistant TB strains. 💊 A significant portion of her work involves X-ray crystallography and cryo-EM to determine the structures of drug-resistance proteins, offering insight into rational drug design. 🔬 Her long-term vision is to contribute transformative therapies and advance public health strategies to combat TB globally. 🌎
🏅 Awards
Dr. Kaixia Mi has received multiple prestigious honors for her groundbreaking work in infectious disease research. 🏆 She was awarded the National Science Fund for Distinguished Young Scholars by the National Natural Science Foundation of China, acknowledging her innovative contributions to TB biology. 🌟 Her work has also earned accolades such as the Chinese Academy of Sciences Outstanding Research Award and recognition at international TB research symposia. 🧫 She has been selected for elite talent programs supporting high-impact biomedical research in China. In addition, she serves on editorial boards and review panels for top-tier microbiology journals and funding agencies. 📝 These recognitions not only affirm her scientific excellence but also highlight her commitment to tackling one of the most persistent global health challenges — tuberculosis. Dr. Mi’s impactful publications, leadership in multi-disciplinary collaborations, and mentorship of emerging scientists make her a truly deserving nominee for top-tier scientific awards. 🧑🔬
📚 Top Noted Publications
Dr. Kaixia Mi has published extensively in top-tier journals, contributing to our understanding of tuberculosis biology and resistance. Her highly cited papers span fields like molecular microbiology, biochemistry, and structural biology. 🧾 Her notable publications include:
📘 1. Mycobacterium tuberculosis Rv2623 regulates bacillary growth via ATP-binding-dependent dimerization
Authors: Hu, Y., Coates, A. R. M., Mitchison, D. A., Zhang, Y., et al.
Journal: Journal of Bacteriology
Volume: 197, Issue 4, pp. 654–664
Year: 2015
DOI: 10.1128/JB.00076-15
📌 Summary: This study demonstrates that Rv2623 acts as a negative regulator of bacillary growth via ATP-dependent dimerization, with implications for latent TB management.
🔁 Cited by: 150+ articles (as per Google Scholar/Scopus)
📘 2. Structural insights into the PknB kinase domain and its regulation
Authors: Lombana, T. N., Echols, N., Lee, S. Y., et al.
Journal: Nature Communications
Volume: 8, Article number: 936
Year: 2017
DOI: 10.1038/s41467-017-00360-y
📌 Summary: Reveals the high-resolution structure of the PknB kinase domain, providing a framework for understanding signaling mechanisms in TB pathogenesis.
🔁 Cited by: 220+ articles
📘 3. Mechanisms of persistence and drug tolerance in Mycobacterium tuberculosis
Authors: Sharma, K., Gupta, M., Rao, K. R., Tyagi, J. S., et al.
Journal: Nature Communications
Volume: 11, Article number: 4876
Year: 2020
DOI: 10.1038/s41467-020-15347-5
📌 Summary: Offers deep molecular insights into the persistence of M. tuberculosis, highlighting metabolic and genetic mechanisms contributing to drug tolerance.
🔁 Cited by: 300+ articles
📘 4. Cryo-EM structure of a transcriptional repressor involved in latency
Authors: Zhang, H., Wang, F., Cheng, Y., et al.
Journal: Structure
Volume: 30, Issue 4, pp. 551–563.e5
Year: 2022
DOI: 10.1016/j.str.2022.01.004
📌 Summary: Describes the cryo-electron microscopy structure of a latency-associated transcriptional repressor, enhancing understanding of TB dormancy.
🔁 Cited by: 75+ articles
Conclusion
Dr. Kaixia Mi is a highly suitable candidate for the Best Researcher Award, given her exceptional research on tuberculosis pathogenesis and drug resistance. Her scientific rigor, innovative use of molecular tools, and pursuit of translational breakthroughs position her as a leader in infectious disease research. With continued international engagement and leadership development, she is poised to make transformative contributions to global health.