JEAN MICHEL BRUNEL | Microbiology | Research Excellence Award

Published on by Molecular Biologist

Dr. Jean Michel Brunel | Microbiology | Research Excellence Award

CRHC | Faculty of Pharmacy | France

Dr. Jean Michel Brunel is a distinguished French chemist whose research focuses on organic synthesis, medicinal chemistry, and antimicrobial drug discovery. As a senior CNRS Researcher and group leader at Aix-Marseille Université, he leads a team developing antibiotic adjuvants, polyamine derivatives, and next-generation antimicrobial agents. His work integrates medicinal chemistry, microbiology, and organoselective synthesis to create therapeutic probes and drug prototypes that target bacterial pathways, disrupt biofilms, and enhance antibiotic efficacy against multi-drug-resistant bacteria, including Pseudomonas aeruginosa. Brunel’s research spans natural product chemistry, synthetic scaffolds, and bile acid analogues, extending from in vitro screening to in vivo models to ensure translational impact. Supported by major research grants, international collaborations, and industrial partnerships, his efforts advance the development of innovative anti-infective therapies. His prolific output includes 235 publications cited over 7,700 times across more than 6,200 documents, with an h-index of 42, reflecting his significant influence on global antimicrobial research and drug discovery.

Profiles: Scopus | ORCID | Google Scholar

Featured Publications

Permeabilize, but choose wisely: Selective antibiotic potentiation through outer membrane disruption in Pseudomonas aeruginosa. International Journal of Molecular Sciences.

Adaptation to cinnamaldehyde shapes Pseudomonas aeruginosa resistance to major antibiotics. Journal of Bacteriology.

Accurate antibiotic accumulation in Enterobacteriaceae isolates expressing efflux pumps. Biochimica et Biophysica Acta Biomembranes.

Don’t miss out on new publications by this author!

Bioinspired syntheses of the marine pyridoacridine alkaloids 2-Bromo and 3-Bromodeoxyamphimedine and structure correction of 2-Bromoamphimedine. Journal of Natural Products.

Efflux-mediated resistance in Enterobacteriaceae: Recent advances and ongoing challenges to inhibit bacterial efflux pumps.

Uric acid, the end-product of purine metabolism, mitigates tau-related abnormalities: Comparison with DOT, a non-antibiotic oxytetracycline derivative. Biomolecules.

 

Getachew Alamnie | Microbiology | Editorial Board Member

Published on by Molecular Biologist

Assist Prof Dr. Getachew Alamnie | Microbiology | Editorial Board Member 

Researcher | Mekdela Amba University | Ethiopia

Dr. Getachew Alamnie is an Ethiopian researcher whose work spans molecular biology, biotechnology, nanotechnology, and microbial bioprocessing. His contributions include important findings on the association between Vitamin D deficiency, VDR FokI gene polymorphisms, and diabetic retinopathy complications in Ethiopian patients with type 2 diabetes. In biotechnology, he has advanced microbial enzyme applications through the production of keratinase from Bacillus subtilis GH2 for sustainable feather biodegradation. Dr. Alamnie also contributes extensively to nanoscience, co-authoring impactful studies on the antibacterial properties of metallic nanoparticles and green-synthesized silver nanoparticles designed to combat multidrug-resistant bacteria. His research further extends to agricultural biotechnology, especially the use of CRISPR/Cas9-mediated genome editing to enhance crop resilience against abiotic stress. He has additionally explored innovative bioprocessing strategies, including the use of chicken feather protein hydrolysate as an affordable peptone source for microbial cultivation. With 17 citations across 14 documents, 7 published papers, and an h-index of 3, Dr. Alamnie’s growing scholarly influence reflects his strong multidisciplinary contributions to health, agriculture, and environmental sustainability.

Profiles: Scopus | ORCID

Featured Publications

Melake, A., Alamnie, G., & Mekonnen, M. Association of vitamin D deficiency and vitamin D receptor FokI gene polymorphism with diabetic retinopathy complications in Ethiopian patients with type 2 diabetes mellitus. International Journal of Immunogenetics.

Girma, A., Mebratie, G., Mekuye, B., Abera, B., Bekele, T., & Alamnie, G. Antibacterial capabilities of metallic nanoparticles and influencing factors. Nano Select.

Adane, M., & Alamnie, G. CRISPR/Cas9 mediated genome editing for crop improvement against abiotic stresses: Current trends and prospects. Functional & Integrative Genomics.

Alamnie, G. Production of keratinase enzyme from B. subtilis GH2 and its application in feather biodegradation. Biomass Conversion and Biorefinery.