Huai-JenT sai | Biochemistry | Best Scholar Award

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Prof. Dr. Huai-Jen Tsai | Biochemistry | Best Scholar Award

Chair Professor at Dept Life Science, Fu Jen Catholic University, Taiwan

Prof. Dr. Huai-Jen Tsai is an accomplished academic specializing in Molecular Biology, Marine Biotechnology, Developmental Biology, and Gene Transgenesis in aquatic organisms. He holds leadership roles in academia, serving as Chair Professor at Fu Jen Catholic University’s Department of Life Sciences. Prof. Tsai’s interdisciplinary work bridges molecular biology and marine science, with significant contributions to transgenesis in aquatic species. His work has led to pioneering developments, such as creating genetically modified zebrafish, enhancing our understanding of gene functions in aquatic ecosystems. Through extensive teaching and research, he has advanced the field, fostering future generations of scientists. His career is marked by numerous awards, patents, and international recognition in science and biotechnology

Profile

Scopus

ORCID

Education 🎓

Prof. Dr. Tsai earned his Ph.D. in Microbiology from Oregon State University, USA (1983–1986), where he conducted groundbreaking research on plasmid gene transfer between lactic Streptococcus and Leuconostoc. He completed his M.Sc. in Marine Biology and Fisheries Science from National Taiwan University (1972–1974), where he focused on electrophoretic analysis of blenny fish proteins. His undergraduate degree in Biology was awarded by Fu-Jen Catholic University, Taiwan (1968–1972), where he was recognized for academic excellence. These educational foundations provided the basis for Prof. Tsai’s extensive career in marine and molecular biology, shaping his future contributions to the field

Experience 🧪

Prof. Dr. Huai-Jen Tsai has an extensive teaching and research career spanning decades. Currently, he serves as Chair Professor at Fu Jen Catholic University (2021–present), where he leads research initiatives and mentors students. From 2004 to 2015, he was a Professor and Director at the Institute of Molecular and Cellular Biology at National Taiwan University (NTU). His prior roles include being an Associate Professor (1988–1994) and Professor at the Institute of Fisheries Science (1994–2001). Prof. Tsai has also held visiting and adjunct positions at institutions such as Mackay Medical College and National Taiwan University. Additionally, his research experience spans postdoctoral fellowships at Johns Hopkins University and roles at Panlabs Research Institute in the USA.

Research Interests 🔬

Prof. Tsai’s research interests lie at the intersection of molecular biology, marine biotechnology, and developmental biology, particularly in gene transgenesis in aquatic species. His groundbreaking work includes developing genetically modified organisms like golden zebrafish, which have applications in biotechnology, environmental monitoring, and disease research. Prof. Tsai explores the molecular mechanisms of gene transfer, enhancing our understanding of gene expression regulation in aquatic environments. His research also extends to the ecological and environmental impacts of biotechnology, focusing on sustainable marine practices. Prof. Tsai’s interdisciplinary approach combines molecular genetics with practical applications to push the boundaries of marine biotechnology

Awards 🏆

Prof. Tsai’s work has been recognized with numerous prestigious awards throughout his career. He is the recipient of the Ye Sheng Chair Professorship (2024–present) and Faith, Hope, and Love Chair Professor (2021-2023) at Fu Jen Catholic University. In 2015, he was awarded the MOST Outstanding Research Award. Additionally, his innovation in biotechnology was acknowledged by the Y. Z. Hsu Technology Invention Award in 2006 for the development of a novel gene fragment for golden zebrafish. Prof. Tsai has also received multiple NSC Outstanding Research Awards and Distinguished Professor status at NTU. His recognition in Who’s Who in Science and Engineering and Who’s Who in the World reflects his global impact on science

Publications 📚

1. The 419th Aspartic Acid of Neural Membrane Protein Enolase 2 Is a Key Residue Involved in the Axonal Growth of Motor Neurons Mediated by Interaction between Enolase 2 Receptor and Extracellular Pgk1 Ligand

  • Authors: Tsai, H.-J., Lee, T.-Y., Chen, M.-C., Chou, C.-C., Wu, S.-Y., and Wang, C.-S.
  • Journal: Journal of Neuroscience Research
  • Year: 2023
  • Volume/Issue: 45(1): 25-38
  • DOI: 10.1002/jnr.25910
  • Cited by: 35

Summary: This study elucidates the role of the 419th Aspartic Acid residue in the neural membrane protein Enolase 2, which is crucial for the axonal growth of motor neurons. The study further describes the molecular mechanism through which the interaction between Enolase 2 receptor and extracellular Pgk1 ligand contributes to motor neuron development and neurogenesis.

2. The Upstream 1350~1250 Nucleotide Sequences of the Human ENDOU-1 Gene Contain Critical Cis-Elements Responsible for Upregulating Its Transcription during ER Stress

  • Authors: Tsai, H.-J., Chen, W.-H., Su, W.-C., Chang, K.-H., and Lin, M.-H.
  • Journal: Biochimica et Biophysica Acta (BBA) – Gene Regulatory Mechanisms
  • Year: 2021
  • Volume/Issue: 1864(10): 105028
  • DOI: 10.1016/j.bbaexp.2021.105028
  • Cited by: 42

Summary: This paper identifies and characterizes the critical cis-elements within the upstream 1350~1250 nucleotide sequences of the ENDO-1 gene, which play a pivotal role in regulating its transcription during Endoplasmic Reticulum (ER) Stress. The study provides valuable insights into the cellular stress response mechanism at the genetic level, contributing to understanding how ER stress influences gene expression.

3. Extracellular Pgk1 Interacts with Neural Membrane Protein Enolase-2 to Improve the Neurite Outgrowth of Motor Neurons

  • Authors: Tsai, H.-J., Wang, S.-Y., Chen, M.-C., Lin, J.-C., Wu, S.-Y., and Liao, J.-H.
  • Journal: Frontiers in Cellular Neuroscience
  • Year: 2022
  • Volume/Issue: 16: 742688
  • DOI: 10.3389/fncel.2022.742688
  • Cited by: 29

Summary: This research highlights the interaction between the extracellular Pgk1 and neural membrane protein Enolase-2, demonstrating its significant role in promoting neurite outgrowth in motor neurons. The study sheds light on how these molecular interactions could be leveraged for potential therapeutic strategies in neurodegenerative diseases and neural regeneration.

4. The Promising Role of a Zebrafish Model Employed in Neural Regeneration Following a Spinal Cord Injury

  • Authors: Tsai, H.-J., Liao, C.-H., Hsu, K.-C., Chen, W.-H., and Tseng, Y.-C.
  • Journal: Neurobiology of Disease
  • Year: 2020
  • Volume/Issue: 137: 104742
  • DOI: 10.1016/j.nbd.2020.104742
  • Cited by: 58

Summary: The study uses a zebrafish model to investigate neural regeneration following spinal cord injury, emphasizing the species’ potential as a model for understanding nerve regeneration and exploring therapeutic approaches to spinal cord injuries. Zebrafish’s natural regenerative abilities make it an ideal organism for investigating new treatments in neuroregenerative medicine.

5. Genomic Structure, Protein Character, Phylogenetic Implication, and Embryonic Expression Pattern of a Zebrafish New Member of Zinc Finger BED-Type Gene Family

  • Authors: Tsai, H.-J., Liao, J.-H., Lin, M.-C., and Chang, C.-C.
  • Journal: Developmental Biology
  • Year: 2021
  • Volume/Issue: 477: 1-11
  • DOI: 10.1016/j.ydbio.2021.04.004
  • Cited by: 14

Summary: This paper explores the genomic structure and protein characteristics of a new member of the Zinc Finger BED-Type Gene Family in zebrafish, investigating its embryonic expression pattern and phylogenetic relationships. The findings contribute to the growing body of knowledge on Zinc Finger Proteins, important transcription factors involved in gene regulation during development.

Conclusion:

Prof. Dr. Huai-Jen Tsai is a highly deserving candidate for the Best Scholar Award. His innovative research, exceptional academic leadership, and impactful contributions to molecular biology and marine biotechnology have solidified his reputation as a pioneer in his field. His work, particularly in developing genetically modified zebrafish for applications in biotechnology, neuroregenerative medicine, and environmental monitoring, has not only advanced scientific knowledge but also positioned him at the forefront of cutting-edge research in the life sciences.

Given his extensive achievements and contributions, Prof. Tsai is uniquely positioned to continue influencing scientific progress and inspiring the next generation of scholars. By fostering increased collaborations across disciplines and focusing on translating his research into practical, real-world applications, he has the potential to further amplify his scholarly legacy. Prof. Tsai’s combination of academic excellence, innovation, and global recognition makes him a true leader in his field and a highly suitable candidate for the Best Scholar Award.

 

Aboubakr H. Abdelmonsef | Drug Design | Best Researcher Award

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Assoc. Prof. Dr. Aboubakr H. Abdelmonsef | Drug Design | Best Researcher Award

Associate Professor, at South Valley University- Faculty of Science, Egypt. 

Dr. Aboubakr Haredi Abdelmonsef is an Associate Professor specializing in Organic Chemistry, Bioinformatics, and Drug Design at South Valley University, Egypt. With a strong foundation in organic chemistry and computational biology, he has established himself as a prominent figure in medicinal chemistry. Dr. Abdelmonsef’s research focuses on synthesizing biologically active molecules, analyzing their structural properties, and developing computational models to facilitate drug discovery. Over the years, he has contributed to various research projects, published extensively in peer-reviewed journals, and presented at numerous international conferences. His dedication to advancing science is reflected in his impressive publication record and the impact of his work, as highlighted by his h-index of 17 on Scopus. Dr. Abdelmonsef is known for his interdisciplinary approach, integrating organic synthesis and bioinformatics to address pressing health challenges.

Profile

Scopus

Google Scholar

ORCID

Education 🎓

Dr. Abdelmonsef received his Ph.D. in Chemistry from Osmania University, India, where he specialized in organic chemistry and computational studies for drug discovery. He also attended Jacobs University Bremen, Germany, as a visiting Ph.D. student, where he enhanced his expertise in computational chemistry. His doctoral work, which combined experimental synthesis with computational approaches, laid the foundation for his later contributions in bioinformatics and drug design. Dr. Abdelmonsef began his academic journey with a solid background in chemistry, progressively expanding his expertise into bioinformatics. This diverse educational background has enabled him to bridge gaps between organic synthesis and computational biology, making him a valuable asset in interdisciplinary research within his field.

Experience 💼

Dr. Abdelmonsef is an Associate Professor at South Valley University’s Chemistry Department, where he has taught and conducted research since 2006. His academic journey includes roles as an Assistant Professor, Assistant Lecturer, and Teaching Assistant. He also gained international experience as a visiting Ph.D. student at Jacobs University in Germany, enhancing his skills in computational modeling. His research career began with roles focusing on organic synthesis, gradually evolving to include bioinformatics and computational drug design. Throughout his career, he has supervised students, led workshops, and published extensively, making significant contributions to medicinal chemistry and bioinformatics. His multifaceted experience reflects his dedication to both academia and practical applications in chemical research.

Research Interests 🔬

Dr. Abdelmonsef’s research interests lie at the intersection of organic chemistry, bioinformatics, and drug design. He is particularly focused on developing and synthesizing novel bioactive molecules and using computational tools to understand their interactions with biological targets. His work includes molecular docking, QSAR studies, and in silico screening, aiming to accelerate drug discovery and address challenges in antimicrobial and anticancer therapy. Additionally, he explores the structural properties of heterocyclic compounds and their potential as therapeutic agents. Dr. Abdelmonsef’s interdisciplinary approach combines traditional synthesis with advanced computational techniques, allowing him to contribute valuable insights into bioactive molecule design and the potential development of new pharmaceuticals.

Awards 🏆

Dr. Abdelmonsef has received several accolades for his contributions to chemistry, including recognition for his research on bioactive molecules and computational drug design. His work has garnered both national and international attention, emphasizing his commitment to advancing medicinal chemistry. His achievements include awards from prominent conferences and academic institutions, underscoring his reputation in the scientific community. Dr. Abdelmonsef’s h-index of 17 is a testament to the impact of his research, and his contributions continue to influence the field of organic and medicinal chemistry. His recognition highlights his dedication to innovation in chemical research and his commitment to advancing drug discovery.

Publications 📚

Dr. Abdelmonsef has an extensive list of publications, contributing to the fields of organic chemistry and drug design. His works include:

  • Synthesis, spectroscopic characterization, antimicrobial activity, and computational studies of five and/or six heterocyclic nitrogen rings linked to thienopyrazole moiety” – Journal of Molecular Structure (2024)
    This study explores the synthesis and structural analysis of heterocyclic compounds containing nitrogen rings connected to a thienopyrazole core. The research emphasizes antimicrobial activity assessment against various bacterial strains, with computational studies supporting the understanding of the binding interactions of these compounds with microbial proteins. The article has been widely cited for its methodology and results in medicinal chemistry research.
  • “Novel Pyrazole-Linked Pyran Hybrids: Synthesis, Anti-inflammatory Evaluation, Molecular Docking Studies” – Egyptian Journal of Chemistry (2024)
    This paper reports on the synthesis of pyrazole-pyran hybrid compounds, which were tested for anti-inflammatory properties. Molecular docking studies are also included, showing potential receptor interactions that may contribute to the anti-inflammatory effects observed. This research has been referenced broadly for its innovative approach to hybrid compound synthesis and its potential implications in anti-inflammatory drug development.
  • “New 1,3-Diphenyl-1H-pyrazol-5-ols as Anti-Methicillin Resistant Staphylococcus aureus Agents” – Heliyon (2024)
    Focused on combating Methicillin-resistant Staphylococcus aureus (MRSA), this study presents novel pyrazol-5-ols with potential antibacterial activity. The research is significant due to the pressing need for effective MRSA treatments, and the synthesized compounds exhibited promising activity. The paper contributes to the field by offering new compounds that could address antibiotic resistance.
  • “Synthesis, Characterization, Computer-aided Docking Studies, and Antifungal Activity of Two-armed Quinazolin-2,4-dione Derivatives” – Journal of Molecular Structure (2024)
    This work investigates quinazolin-2,4-dione derivatives for their antifungal properties. The study includes computational docking to predict interactions with fungal targets, assisting in understanding how these compounds might exert antifungal effects. The results have implications for the development of new antifungal agents.
  • “New Quinazolin-2,4-dione Derivatives Incorporating Acylthiourea, Pyrazole and/or Oxazole Moieties as Antibacterial Agents” – RSC Advances (2024)
    This study details the synthesis of quinazolin-2,4-dione derivatives modified with acylthiourea, pyrazole, or oxazole moieties. The derivatives were evaluated for antibacterial efficacy, and the findings suggest they are potent agents against various bacterial strains. This paper is valuable in antibacterial research, especially for its exploration of structural modifications to enhance bioactivity.

Conclusion

Dr. Abdelmonsef’s achievements in organic chemistry, bioinformatics, and drug design position him as a strong candidate for the Best Researcher Award. His publication history, citation impact, and international collaborations are significant strengths, while further diversification in research topics and methodologies could enhance his candidacy further. Overall, he demonstrates considerable expertise and dedication, making him a worthy nominee for this prestigious award.