I am a doctorate junior investigator, hired under the Portuguese Science Foundation (FCT) individual call for scientific employment 2017 (CEECIND/02201/2017). I graduated in Biology from the University of Coimbra (UC) in 2007 and completed a master’s degree in Cellular and Molecular Biology from UC in 2008, scoring 18 out of 20. I obtained my Ph.D. in Cellular Biology from UC in 2013, achieving the highest distinction: Summa cum laude. In 2015, I was awarded a science management fellowship, and from 2016 to 2019, I received a national post-doc fellowship from FCT.
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ACADEMIC EDUCATION:
- 1985: B.S. Agricultural Chemistry, Kyungpook National University, Taegu, Korea. 1987: M.S. Agricultural Chemistry, Kyungpook National University, Taegu, Korea. 1994: Ph.D. Biochemistry, University of Maryland, College Park, MD., USA. 1999: Post Doctoral Fellow, Laboratory of Biochemical Physiology, NCI, Frederick, USA
APPOINTMENTS AND PROFESSIONAL ACTIVITIES:
1983-1984: Army service, Taegu, Korea. 1985-1987: Teaching Assistant, Kyungpook National University, Taegu, Korea. 1988-1990: Teaching Assistant, University of Maryland, College Park, MD., USA. 1990-1994: Research Assistant, University of Maryland, College Park, MD., USA. 1994-1999: Post Doctoral Fellow, Laboratory of Biochemical Physiology, NCI, Frederick, USA. 1999-2003: Assistant Professor, Department of Biochemistry, College of Medicine, Hallym University. 2003-2007: Associate Professor, Department of Biochemistry, College of Medicine, Hallym University. 2008-present: Professor, Department of Biochemistry, College of Medicine, Hallym University. 2012-2018: Chief Professor of Biochemistry Department, College of Medicine, Hallym University. 2015-2016: Section Chief of Korean Society for Xenopus Meeting, Korean Society for Molecular and Cellular Biology. 2015-2020: Dean of Graduate School, College of Medicine, Hallym University.
RESEARCH FIELDS AND INTERESTS
Dr. Kim has made significant contributions to the field of biochemistry. He obtained his B.S. and M.S. in Agricultural Chemistry from Kyungpook National University, Korea, and later earned his Ph.D. in Biochemistry from the University of Maryland, USA. Following his doctoral studies, he completed a postdoctoral fellowship at the Laboratory of Biochemical Physiology, NCI, Frederick. Dr. Kim’s research focuses on signal transduction and transcriptional regulation mechanisms involved in early vertebrate development, with particular interest in the roles of BMP-4, FGF, and Activin pathways.
PROJECTS (2016-present):
- National Research Foundation of Korea [2016R1D1A1B02008770]: Coordinated Molecular Network between Key Signaling Pathways vs Primary Response Gene Expression and Fate Determination in Early Vertebrate Development. Principal Investigator. 49,750,000 won/yr (2016-2024). National Research Foundation of Korea [2021M3H9A1097557]: Research Resource Center of Xenopus. Principal Investigator. 100,000,000 won/yr (2021-2026). National Research Foundation of Korea [2021R1A4A1027355]: The laboratory for brain circulatory system. Participant as a Basic Research Laboratory Fund. 100,000,000 won/yr (2021-2024). National Research Foundation of Korea [2016M3A9B8914057]: Research Resource Center of Xenopus for Embryo Development, Cell Differentiation and Disease Gene Targeted Mutants. Principal Investigator. 100,000,000 won/yr (2016-2021). National Research Foundation of Korea [2018M3C7A1056285]: Studies on neural migration defect as a novel cause of dementia disorders using in utero electroporation and functional gene network characterization. Principal Investigator. 84,164,000 won/yr (2018-2022)
Publications
- Xbra modulates the activity of linker region phosphorylated Smad1 during Xenopus development
Kumar S, Umair Z, Kumar V, Goutam RS, Park S, Lee U, Kim J. Sci Rep. 2024 Apr 18;14(1):8922. doi: 10.1038/s41598-024-59299-7.
- Cdx1 and Gsc distinctly regulate the transcription of BMP4 target gene ventx3.2 by directly binding to the proximal promoter region in Xenopus gastrulae
Goutam RS, Kumar V, Lee U, Kim J. Mol Cells. 2024 Apr;47(4):100058. doi: 10.1016/j.mocell.2024.100058. Epub 2024 Mar 23.
- Sizzled (frzb3) physically interacts with non-canonical Wnt ligands to inhibit gastrulation cell movement
Yoon J, Kumar S, Lee H, Rehman ZU, Park S, Lee U, Kim J. Mol Cells. 2024 May 15:100068. doi: 10.1016/j.mocell.2024.100068. Online ahead of print.
- Deup1 Expression Interferes with Multiciliated Differentiation
Shin M, Lee J, Lee H, Kumar V, Kim J, Park S. Mol Cells. 2023 Dec 31;46(12):746-756.
- Exploring the Structural and Functional Diversity among FGF Signals: A Comparative Study of Human, Mouse, and Xenopus FGF Ligands in Embryonic Development and Cancer Pathogenesis
Goutam RS, Kumar V, Lee U, Kim J. Int J Mol Sci. 2023 Apr 20;24(8):7556.
- Two Homeobox Transcription Factors, Goosecoid and Ventx1.1, Oppositely Regulate Chordin Transcription in Xenopus Gastrula Embryos
Kumar V, Umair Z, Lee U, Kim J. Cells. 2023 Mar 11;12(6):874.
- Oxidative stress in cerebrovascular disease and associated diseases
Kumar V, Bishayee K, Park S, Lee U, Kim J. Front Endocrinol (Lausanne). 2023 Feb 17;14:1124419.
- Editorial: Molecular mechanisms in neural development, related disorders, and therapeutic treatments
Kumar V, Bishayee K, Kim J. Front Mol Neurosci. 2023 Jan 13;16:1135491.
- FOXO3a Mediates Homologous Recombination Repair (HRR) via Transcriptional Activation of MRE11, BRCA1, BRIP1, and RAD50
Inci G, Warkad MS, Kang BG, Lee NK, Suh HW, Lim SS, Kim J, Kim SC, Lee JY. Molecules. 2022 Dec 6;27(23):8623.
- Bmp4 Synexpression Gene, Sizzled, Transcription Is Collectively Modulated by Smad1 and Ventx1.1/Ventx2.1 in Early Xenopus Embryos
Rehman ZU, Tayyaba F, Lee U, Kim J. Int J Mol Sci. 2022 Nov 1;23(21):13335.
- Reversing the HDAC-inhibitor mediated metabolic escape in MYCN-amplified neuroblastoma
Bishayee K, Nazim UM, Kumar V, Kang J, Kim J, Huh SO, Sadra A. Biomed Pharmacother. 2022 Jun;150:113032.
- Ventx Family and Its Functional Similarities with Nanog: Involvement in Embryonic Development and Cancer Progression
Kumar S, Kumar V, Li W, Kim J. Int J Mol Sci. 2022 Mar 1;23(5):2741.
- Bmp Signal Gradient Modulates Convergent Cell Movement via Xarhgef3.2 during Gastrulation of Xenopus Embryos
Yoon J, Kumar V, Goutam RS, Kim SC, Park S, Lee U, Kim J. Cells. 2021 Dec 24;11(1):44.
- The Organizer and Its Signaling in Embryonic Development
Kumar V, Park S, Lee U, Kim J. J Dev Biol. 2021 Nov 1;9(4):47.
- Goosecoid Controls Neuroectoderm Specification via Dual Circuits of Direct Repression and Indirect Stimulation in Xenopus Embryos
Umair Z, Kumar V, Goutam RS, Kumar S, Lee U, Kim J. Mol Cells. 2021 Oct 31;44(10):723-735.